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· · COA & SDS Disponível para todos os produtos · Envio no mesmo dia em itens em estoque BPN14770 - Moligand™, ≥98% , Allosteric modulator of phosphodiesterase 4D, CAS No.1606974-33-7, Allosteric modulator of phosphodiesterase 4D
Disponível para encomenda
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98% Synonyms
ZATOLMILAST [INN] | Zatolmilast | HY-117571 | 2-(4-{[2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl]methyl}phenyl)acetic acid | 1606974-33-7 | s6844 | Benzeneacetic acid, 4-((2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl)methyl)- | 2-[4-[[2-(3-ch
Shipped In
Ice chest + Ice pads
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Why this grade Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Visão geral Information
BPN14770 is a selective allosteric inhibitor ofphosphodiesterase 4D (PDE4D)with IC50 of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively.
Targets
PDE4D3 (Cell-free assay); PDE4D7 (Cell-free assay) 7.4 nM; 7.8 nM
Specifications Sinónimos
ZATOLMILAST [INN] | Zatolmilast | HY-117571 | 2-(4-{[2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl]methyl}phenyl)acetic acid | 1606974-33-7 | s6844 | Benzeneacetic acid, 4-((2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl)methyl)- | 2-[4-[[2-(3-ch
Especificações e pureza
Moligand™, ≥98%
Mecanismos bioquímicos e fisiológicos
BPN14770 is a selective allosteric inhibitor of phosphodiesterase 4D (PDE4D) with IC50 of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively.
Condições de armazenamento de armazenamento
Store at -20°C
Enviado em
Ice chest + Ice pads
Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.
Tipo de ação
ALLOSTERIC MODULATOR
Mecanismo de ação
Allosteric modulator of phosphodiesterase 4D
Propriedades do produto ALogP 6.3 hba_count 2 Ligação rotativa 6
Nomes e identificadores Pubchem Sid 504772561 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504772561 Sorrisos canónicos C1=CC(=CC(=C1)Cl)C2=NC(=CC(=C2)CC3=CC=C(C=C3)CC(=O)O)C(F)(F)F IUPAC Name 2-[4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl]methyl]phenyl]acetic acid InChIKey LTSUMTMGJHPGFX-UHFFFAOYSA-N INCHI 1S/C21H15ClF3NO2/c22-17-3-1-2-16(12-17)18-9-15(10-19(26-18)21(23,24)25)8-13-4-6-14(7-5-13)11-20(27)28/h1-7,9-10,12H,8,11H2,(H,27,28) SMILES isoméricas C1=CC(=CC(=C1)Cl)C2=NC(=CC(=C2)CC3=CC=C(C=C3)CC(=O)O)C(F)(F)F CAS alternativo 1606974-33-7 Termos de entrada MeSH 2-(4-((2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl)methyl)phenyl)acetic acid;BPN14770 Peso molecular 405.8 Reaxy-Rn 26827686 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=26827686&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds Classe Pyridines and derivatives Subclass Phenylpyridines Intermediate Tree Nodes Not available Direct Parent Phenylpyridines Alternative Parents Chlorobenzenes Aryl chlorides Heteroaromatic compounds Monocarboxylic acids and derivatives Carboxylic acids Azacyclic compounds Organonitrogen compounds Organofluorides Organochlorides Organic oxides Hydrocarbon derivatives Carbonyl compounds Alkyl fluorides Molecular Framework Aromatic heteromonocyclic compounds Substituents 2-phenylpyridine - Chlorobenzene - Halobenzene - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Benzenoid - Heteroaromatic compound - Carboxylic acid derivative - Azacycle - Carboxylic acid - Monocarboxylic acid or derivatives - Alkyl fluoride - Organohalogen compound - Organochloride - Organofluoride - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Carbonyl group - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Alkyl halide - Aromatic heteromonocyclic compound Descrição This compound belongs to the class of organic compounds known as phenylpyridines. These are polycyclic aromatic compounds containing a benzene ring linked to a pyridine ring through a CC or CN bond. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Estrutura 3D Alvos associados (humanos) Alvos associados (não humanos) Mecanismos de ação Certificados（CoA,COO,BSE/TSE e Mapa de Análise) Propriedades químicas e físicas Solubilidade Solubility (25°C) In vitro DMSO: 81 mg/mL (199.6 mM); Ethanol: 81 mg/mL (199.6 mM); Water: ˂1 mg/mL DMSO (mg/mL) Solubilidade máxima 81 DMSO (mM) Solubilidade máxima 199.605717102021 Água (mg/mL) Solubilidade máxima ˂1 Peso molecular 405.800 g/mol XLogP3 5.400 Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 6 Rotatable Bond Count 5 Exact Mass 405.074 Da Monoisotopic Mass 405.074 Da Topological Polar Surface Area 50.200 Ų Heavy Atom Count 28 Formal Charge 0 Complexity 522.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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