Bumetanide - Moligand™, 10mM in DMSO , Sodium-(potassium)-chloride cotransporter 2 inhibitor, CAS No.28395-03-1, Sodium-(potassium)-chloride cotransporter 2 inhibitor

CAS: 28395-03-1 Cat. No.: B407775 Fórmula: C₁₇H₂₀N₂O₅S Peso molecular: 364.42 Número CE: 249-004-6

GRAU & PUREZA Moligand™, 10mM in DMSO

Synonyms

Benzoic acid, 3-(aminosulfonyl)-5-(butylamino)-4-phenoxy-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

Bumetanide Bumetanide (Bumex) is a loop diuretic of the sulfamyl category to treat heart failure. Bumetanide is a selective Na+-K+-Cl- cotransporter 1 (NKCC1) inhibitor, weakly inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respe
In vitro

In vivo

Cell Data

cell lines：MV-4-11, MM.1S, and K562 cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

Especificações

Sinónimos

Benzoic acid, 3-(aminosulfonyl)-5-(butylamino)-4-phenoxy-

Especificações e pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos e fisiológicos

Bumetanide (Bumex) is a loop diuretic of the sulfamyl category to treat heart failure. Bumetanide is a selective Na+-K+-Cl- cotransporter 1 (NKCC1) inhibitor, weakly inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Tipo de ação

AGONIST, INHIBITOR

Mecanismo de ação

Sodium-(potassium)-chloride cotransporter 2 inhibitor

Propriedades do produto

ALogP

2.8

Nomes e identificadores

SMILES isoméricas

CCCCNC1=C(C(=CC(=C1)C(=O)O)S(=O)(=O)N)OC2=CC=CC=C2

WGK Alemanha

3

RTECS

DG4910000

Peso molecular

364.42

Reaxy-Rn

2185351

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2185351&ln=

Alvos associados (humanos)

SLC12A1 Tclin Solute carrier family 12 member 1 (1 Activities)

Discover Target: SLC12A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC12A2 Tclin Solute carrier family 12 member 2 (1 Activities)

Discover Target: SLC12A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Perguntas frequentes

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 28395-03-1, the molecular formula is C17H20N2O5S, and the molecular weight is 364.42 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.