CDPPB - Moligand™,≥99% , CAS No.781652-57-1

CAS: 781652-57-1 Cat. No.: C1433451 Fórmula: C₂₃H₁₆N₄O Peso molecular: 364.40 Número CE: 694-419-1

GRADE & PURITY Moligand™, ≥99%

Synonyms

3-Cyano-N-1,3-diphenyl-1H-pyrazol-5-yl)benzamide

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

CDPPB is a potent, selective and brain penetrant positive allosteric modulator of the metabotropic glutamate receptor subtype 5 ( mGluR5 ) , with an EC 50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5. CDPPB may provide an approach for development of antipsychotic agents.

Specifications

Sinónimos

3-Cyano-N-1,3-diphenyl-1H-pyrazol-5-yl)benzamide

Especificações e pureza

Moligand™,≥99%

Mecanismos bioquímicos e fisiológicos

Activation of metabotropic glutamate 5 receptor by CDPPB enhances the function of NMDA receptor and markers of neuronal plasticity. This improves recognition memory and cognition deficits in schizophrenia. CDPPB is a glutamate metabotropic mGluR5 positive

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Tipo de ação

MODULATOR

Pureza

≥99%

Nomes e identificadores

• Sorrisos canónicos: C1=CC=C(C=C1)C2=NN(C(=C2)NC(=O)C3=CC=CC(=C3)C#N)C4=CC=CC=C4
• IUPAC Name: 3-cyano-N-(2,5-diphenylpyrazol-3-yl)benzamide
• InChIKey: BKUIZWILNWHFHD-UHFFFAOYSA-N
• INCHI: 1S/C23H16N4O/c24-16-17-8-7-11-19(14-17)23(28)25-22-15-21(18-9-3-1-4-10-18)26-27(22)20-12-5-2-6-13-20/h1-15H,(H,25,28)
• SMILES isoméricas: C1=CC=C(C=C1)C2=NN(C(=C2)NC(=O)C3=CC=CC(=C3)C#N)C4=CC=CC=C4
• WGK Alemanha: 3
• Peso molecular: 364.40

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Azoles
      • Subclass Pyrazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Azoles
• Subclass: Pyrazoles
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylpyrazoles
• Alternative Parents: Benzamides Benzoyl derivatives Benzonitriles Heteroaromatic compounds Secondary carboxylic acid amides Nitriles Azacyclic compounds Organooxygen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Phenylpyrazole - Benzamide - Benzoic acid or derivatives - Benzonitrile - Benzoyl - Monocyclic benzene moiety - Benzenoid - Heteroaromatic compound - Secondary carboxylic acid amide - Carboxamide group - Nitrile - Carbonitrile - Carboxylic acid derivative - Azacycle - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Cyanide - Organic oxygen compound - Organic nitrogen compound - Aromatic heteromonocyclic compound
• Descrição: This compound belongs to the class of organic compounds known as phenylpyrazoles. These are compounds containing a phenylpyrazole skeleton, which consists of a pyrazole bound to a phenyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y