Cefoperazone - Moligand™, 10mM in DMSO , CAS No.62893-19-0

CAS: 62893-19-0 Cat. No.: C408712 Fórmula: C₂₅H₂₇N₉O₈S₂ Peso molecular: 645.67 Número CE: 263-749-4

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

(6R,​7R)​-7-​[[(2R)​-​2-​[[(4-​ethyl-​2,​3-​dioxo-​1-​piperazinyl)​carbonyl]​amino]​-​2-​(4-​hydroxyphenyl)​acetyl]​amino]​-​3-​[[(1-​methyl-​1H-​tetrazol-​5-​yl)​thio]​methyl]​-​8-​oxo-5-​thia-​1-​azabicyclo[4.2.0]​oct-​2-​ene-​2-​carboxylic acid

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

Cefoperazone Cefoperazone is a cephalosporin antibiotic for inhibition of rMrp2-mediated [ 3 H]E 2 17βG uptake with IC50 of 199 μM.
In vitro

In vivo

After intravenous administration of 2 g of Cefoperazone, levels in serum rang from 202μg/mL to 375 μg/mL depending on the period of drug administration. After intramuscular injection of 2 g of Cefoperazone, the mean peak serum level is 111 μg/mL at 1.5 hours. At 12 hours after dosing, mean serum levels are still 2 to 4 μg/mL. Cefoperazone is 90% bound to serum proteins.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

(6R,​7R)​-7-​[[(2R)​-​2-​[[(4-​ethyl-​2,​3-​dioxo-​1-​piperazinyl)​carbonyl]​amino]​-​2-​(4-​hydroxyphenyl)​acetyl]​amino]​-​3-​[[(1-​methyl-​1H-​tetrazol-​5-​yl)​thio]​methyl]​-​8-​oxo-5-​thia-​1-​azabicyclo[4.2.0]​oct-​2-​ene-​2-​carboxylic acid

Especificações e pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos e fisiológicos

Cefoperazone is a cephalosporin antibiotic for inhibition of rMrp2-mediated [³H]E₂17βG uptake with IC50 of 199 μM.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Tipo de ação

INHIBITOR

Nomes e identificadores

• SMILES isoméricas: CCN1CCN(C(=O)C1=O)C(=O)N[C@H](C2=CC=C(C=C2)O)C(=O)N[C@H]3[C@@H]4N(C3=O)C(=C(CS4)CSC5=NN=NN5C)C(=O)O
• Peso molecular: 645.67
• Reaxy-Rn: 603333
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=603333&ln=

Alvos associados (humanos)

SLC22A6 Tclin Solute carrier family 22 member 6 (1 Activities)

Discover Target: SLC22A6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propriedades químicas e físicas

• Solubilidade: Solubility (25°C) In vitro DMSO: 100 mg/mL (138.93 mM)
• Ponto de fusão (°C): 173 °C(dec.)

Referências

1. Yexuan Mao, Yichao Fan, Ran Yang, Youyi Wang, Qingyue Li, Meng Dang, Xianqing Huang, Lianjun Song, Pingan Zhang, Miao Song, Liang Liu, Linli Wang, Shun Yu, Qiuyan Zhao, Xiya Zhang.  (2023)  A highly sensitive electrochemical sensor derived from peptide amphiphilic inspired self-assembled, ordered gold nanoparticles for determination of 22 β-lactams.  ELECTROCHIMICA ACTA,      [PMID:] [10.1016/j.electacta.2023.142669]

2. Shuangmin Wu, Wei Shen, Yushuang Chen, Yongli Zhu, Ren Hou, Menghong Dai, Dapeng Peng.  (2022)  Rapid Determination of Cephalexin in Animal-Derived Food by an Indirect Competitive Enzyme-Linked Immunosorbent Assay.  ANALYTICAL LETTERS,      [PMID:] [10.1080/00032719.2022.2072857]

3. Menghan Qin, Yumiao Shi, Dingkun Lu, Jingjing Deng, Guoyue Shi, Tianshu Zhou.  (2022)  High-performance Hf/Ti-doped defective Zr-MOFs for cefoperazone adsorption: Behavior and mechanisms.  APPLIED SURFACE SCIENCE,      [PMID:] [10.1016/j.apsusc.2022.153494]

4. Cheng Lin, Jiarun Mao, Yihui Chen, Chunyan Hou, Xiaoqiang Qiao, Ningkun Wu, Tingting Wang.  (2025)  A halloysite nanotubes-based hybrid fluorous monolith as the mixed-mode sorbent for hydrophilic and hydrophobic interactions and its application for analysis of antibiotics from milk powder and milk samples.  FOOD CHEMISTRY,      [PMID:39986074] [10.1016/j.foodchem.2025.143440]

5. Pingping Yuan, Shijie Zhou, Qianqian Li, Lin Li, Shaoqi Qu.  (2025)  Extracellular vesicles enhance the efficacy of ceftiofur against intracellular bacterial infections.  Synthetic and Systems Biotechnology,      [PMID:40727487] [10.1016/j.synbio.2025.07.001]