Coppersensor 1 - Moligand™, ≥98% , CAS No.874748-20-6

CAS: 874748-20-6 Cat. No.: C648814 Fórmula: C₃₀H₅₀BF₂N₃S₄ Peso molecular: 629.81

GRADE & PURITY Moligand™, ≥98%

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

Coppersensor-1 (CS1) is a membrane-permeable fluorescent dye. Coppersensor-1 has a picomolar affinity for Cu + with high selectivity over competing cellular metalions. Coppersensor-1 as a probe, can selective and sensitive detection of copper(I) ions (Cu + ) in biological samples, including live cells. Coppersensor-1 can be used for the research of imaging of severe diseases such as cancer , cardiovascular disorders and neurogenerative diseases.

In Vitro

Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs). A. Preparation of reagent stock solutions for imaging: 1. Prepare a 1 mM stock solution of CS1 (MW 630 g/moL) in DMSO by dissolving 0.63 mg of solid CS1 per milliliter of DMSO solvent. 2. Prepare a 10 mM stock solution of CuCl 2 (MW 134 g/moL) by dissolving 1.34 mg of solid CuCl 2 per milliliter of Millipore water solvent. B. CS1 labeling of live cells: 1. Imaging experiments with cells will require 1-2 d with cells in culture. Incubate the cells according to your normal protocol. 2. One day before imaging, cells are passaged and plated on 18-mm glass coverslips coated with poly-L-lysine (50 μg/mL). Adherent cells for imaging are grown to 50-80% confluency. 3. Remove cells from incubator, and transfer one coverslip into a 35-mm Petri dish containing 3 mL PBS buffer. 4. To the Petri dish, add 15 μL of a 1 mM CS1 stock solution to give a final dye concentration of 5 μM. Mix thoroughly. (Higher concentrations of dye may result in high levels of background fluorescence) 5. Incubate for 5-20 min in the dark at 25 or 37℃. C. Imaging the CS1-labeled cells: 1. Imageing in standard confocal microscope with 543 nm excitation. (CS1 can be imaged using any type of fluorescence microscope, including epifluorescence, confocal and multiphoton) MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

Specifications

Especificações e pureza

Moligand™, ≥98%

Mecanismos bioquímicos e fisiológicos

Coppersensor-1 (CS1) is a membrane-permeable fluorescent dye . Coppersensor-1 has a picomolar affinity for Cu + with high selectivity over competing cellular metalions. Coppersensor-1 as a probe, can selective and sensitive detection of copper(I) ions (Cu

Condições de armazenamento de armazenamento

Protected from light,Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Pureza

≥98%

Nomes e identificadores

• Sorrisos canónicos: [F-][B+3]1([N]2=C(C)C(CC)=C(C)C2=C(CN(CCSCCSCC)CCSCCSCC)C3=C(C)C(CC)=C(C)[N-]31)[F-]
• Peso molecular: 629.81

Propriedades químicas e físicas

• Solubilidade: DMSO : 25 mg/mL (39.69 mM; Need ultrasonic)

Referências

1. Ding Tan, Yan Sun, Xudong Li, Ya Wang, Xianbin Sun, Haijun Chen, Yuxiang Lin, Yu Gao.  (2026)  Bone-Penetrating Copper-Coordinated Nanoassembly Elicits Cuproptosis for Multimodal Cancer Therapy.  ACS Applied Materials & Interfaces,      [PMID:41641635] [10.1021/acsami.5c25793]

2. Hui Zhang, Xu Zhu, Jingchun Wang, Yibo Huo, Yikai Ma, Shengzhong Rong, Yuting Lu, Yingxue Jin.  (2026)  Lactate metabolism regulation enhances cuproptosis to activate antitumor immunity: Synergistic therapy of hyaluronic acid nanomicelles delivering lactate oxidase/copper-doped carbon dots combined with α-PD-L1 inhibits distant tumors.  Materials Today Bio,      [PMID:42568871] [10.1016/j.mtbio.2026.103508]

Perguntas frequentes

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C, protected from light. The material is light-sensitive — keep it in its original opaque or amber container.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 874748-20-6, the molecular formula is C30H50BF2N3S4, and the molecular weight is 629.81 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.