CP-547632 TFA - 10mM in DMSO , CAS No.C661611(DMSO)

CAS: C661611(DMSO) Cat. No.: C661611 Fórmula: C₂₂H₂₅BrF₅N₅O₅S Peso molecular: 646.43

GRAU & PUREZA 10mM in DMSO

Storage

Argon charged,Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

CP-547632 TFA is an orally active, ATP-competitive and potent VEGFR-2 and FGF kinases inhibitor with IC 50 s of 11 nM and 9 nM, respectively. CP-547632 TFA is selective for VEGFR2 and bFGF over EGFR , PDGFRβ , and related tyrosine kinases (TKs). CP-547632

IC50& Target:VEGFR2 11 nM (IC 50 ) FGFR 9 nM (IC 50 )

In Vitro:CP-547632 TFA (1-1000 nM; 1 hours) inhibits VEGF-stimulated VEGFR-2 phosphorylation in a dose-dependent fashion, with an IC 50 value of 6 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot

In Vivo:CP-547632 TFA (p.o.; 6.25-100mg/kg/day; for 10-24 days) causes a dose-dependent inhibition of growth in Colo-205, DLD-1, and MDA-MB-231 xenografts. CP-547632 TFA (oral; 50mg/kg; a single oral dose) yieldes plasma concentrations above 500 ng/ml for

Biological Activity:CP-547632 TFA is an orally active, ATP-competitive and potent VEGFR-2 and FGF kinases inhibitor with IC 50 s of 11 nM and 9 nM, respectively. CP-547632 TFA is selective for VEGFR2 and bFGF over EGFR , PDGFRβ , and related tyrosine kinases (TKs). CP-547632

Especificações

Especificações e pureza

10mM in DMSO

Condições de armazenamento de armazenamento

Argon charged,Desiccated,Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

INHIBITOR

Nomes e identificadores

Peso molecular

646.43

Perguntas frequentes

How should this product be stored?

Store at ?80 °C, desiccated, under argon. It is supplied under an argon blanket; reseal under inert gas after each use.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is C661611(DMSO), the molecular formula is C22H25BrF5N5O5S, and the molecular weight is 646.43 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.