Curcumin analog C1 - ≥97% , CAS No.39777-61-2

CAS: 39777-61-2 Cat. No.: C413625 Fórmula: C₁₉H₁₈O₃ Peso molecular: 294.34 Número CE: 873-543-1

GRAU & PUREZA ≥97%

Synonyms

MFCD00719180 | (1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1, | AB00092085-01 | TFEB activator 1 | D82401 | BDBM50285603 | TFEB activator 1; ABM-7612 | S6769 | 1,5-bis-(2-methoxyphenyl)-1,4-pentadien-3-one | 1,5-bis(2-methoxyphenyl)-1,4-pentadien-3-one | (1E,4E

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

Information

Curcumin analog C1 (Curcumin analog Compound C1) is a potenttranscription factor EB (TFEB)activator with promise for the prevention or treatment of Alzheimer's disease.

Especificações

Sinónimos

MFCD00719180 | (1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1, | AB00092085-01 | TFEB activator 1 | D82401 | BDBM50285603 | TFEB activator 1; ABM-7612 | S6769 | 1,5-bis-(2-methoxyphenyl)-1,4-pentadien-3-one | 1,5-bis(2-methoxyphenyl)-1,4-pentadien-3-one | (1E,4E

Especificações e pureza

≥97%

Mecanismos bioquímicos e fisiológicos

TFEB activator 1 is an orally effective, mTOR-independent activator of TFEB. TFEB activator 1 significantly promotes the nuclear translocation of Flag-TFEB with an EC50 of 2167 nM. TFEB activator 1 enhances autophagy without inhibiting the mTOR pathway an

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Pureza

≥97%

Nomes e identificadores

Pubchem Sid

504760246

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504760246

Sorrisos canónicos

COC1=CC=CC=C1C=CC(=O)C=CC2=CC=CC=C2OC

IUPAC Name

(1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one

InChIKey

RCZMPCUUTSDNAJ-PHEQNACWSA-N

INCHI

1S/C19H18O3/c1-21-18-9-5-3-7-15(18)11-13-17(20)14-12-16-8-4-6-10-19(16)22-2/h3-14H,1-2H3/b13-11+,14-12+

SMILES isoméricas

COC1=CC=CC=C1/C=C/C(=O)/C=C/C2=CC=CC=C2OC

Peso molecular

294.34

Reaxy-Rn

2335342

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2335342&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Phenol ethers
      • Subclass Anisoles

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Phenol ethers
• Subclass: Anisoles
• Intermediate Tree Nodes: Not available
• Direct Parent: Anisoles
• Alternative Parents: Styrenes Phenoxy compounds Methoxybenzenes Alkyl aryl ethers Enones Acryloyl compounds Ketones Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Phenoxy compound - Anisole - Styrene - Methoxybenzene - Alkyl aryl ether - Monocyclic benzene moiety - Enone - Acryloyl-group - Alpha,beta-unsaturated ketone - Ketone - Ether - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Organic oxide - Organic oxygen compound - Aromatic homomonocyclic compound
• Descrição: This compound belongs to the class of organic compounds known as anisoles. These are organic compounds containing a methoxybenzene or a derivative thereof.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Alvos associados (humanos)

HL-60 (67320 Activities)

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RPMI-7951 (420 Activities)

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HCT-116 (91556 Activities)

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KB (17409 Activities)

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HeLa (62764 Activities)

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MDA-MB-231 (73002 Activities)

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Alvos associados (não humanos)

Plasmodium falciparum (966862 Activities)

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Luciferin 4-monooxygenase (66902 Activities)

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Mecanismos de ação

Propriedades químicas e físicas

• Solubilidade: DMSO: 59 mg/mL (200.45 mM)Ethanol: 2 mg/mL (6.79 mM)
• Peso molecular: 294.300 g/mol
• XLogP3: 4.100
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 294.126 Da
• Monoisotopic Mass: 294.126 Da
• Topological Polar Surface Area: 35.500 Ų
• Heavy Atom Count: 22
• Formal Charge: 0
• Complexity: 363.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 2
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 2
• Covalently-Bonded Unit Count: 1