D-3263 hydrochloride - ≥98% , CAS No.1008763-54-9

CAS: 1008763-54-9 Cat. No.: D650364 Fórmula: C₂₁H₃₂ClN₃O₃ Peso molecular: 409.95 PubChem CID: 49787136

GRADE & PURITY ≥98%

Synonyms

3-(2-Amino-ethyl)-1(R)-((2(S)-isopropyl-5(R)-methyl cyclohexanecarbonyl))-5-methoxy-1,3-dihydro-benzoimidazol-2-one hydrochloride | UNII-R82GTC01OB | 1008763-54-9 | AKOS032945009 | D-3263 hydrochloride | HY-16162A | F85439 | R82GTC01OB | EC D-3263 HCl | 3

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Visão geral

D-3263 hydrochloride is an enteric-coated, orally bioavailable (transient receptor potential melastatin member 8) TRPM8 agonist.

In Vitro

D-3263 hydrochloride binds to and activates TRPM8, which may result in an increase in calcium and sodium entry; the disruption of calcium and sodium homeostasis; and the induction of cell death in TRPM8-expressing tumor cells. D-3263 hydrochloride may decrease dihydrotestosterone (DHT) levels, which may contribute to its inhibitory effects on prostate cancer and BPH. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

Specifications

Sinónimos

3-(2-Amino-ethyl)-1(R)-((2(S)-isopropyl-5(R)-methyl cyclohexanecarbonyl))-5-methoxy-1,3-dihydro-benzoimidazol-2-one hydrochloride | UNII-R82GTC01OB | 1008763-54-9 | AKOS032945009 | D-3263 hydrochloride | HY-16162A | F85439 | R82GTC01OB | EC D-3263 HCl | 3

Especificações e pureza

≥98%

Mecanismos bioquímicos e fisiológicos

D-3263 hydrochloride is an enteric-coated, orally bioavailable (transient receptor potential melastatin member 8) TRPM8 agonist.

Condições de armazenamento de armazenamento

Store at 2-8°C,Desiccated

Enviado em

Wet ice

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

AGONIST

Pureza

≥98%

Nomes e identificadores

Sorrisos canónicos

CC1CCC(C(C1)C(=O)N2C3=C(C=C(C=C3)OC)N(C2=O)CCN)C(C)C.Cl

IUPAC Name

3-(2-aminoethyl)-5-methoxy-1-[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexanecarbonyl]benzimidazol-2-one;hydrochloride

InChIKey

DYMRNRVXSXCQHZ-UANXYBPYSA-N

INCHI

1S/C21H31N3O3.ClH/c1-13(2)16-7-5-14(3)11-17(16)20(25)24-18-8-6-15(27-4)12-19(18)23(10-9-22)21(24)26;/h6,8,12-14,16-17H,5,7,9-11,22H2,1-4H3;1H/t14-,16+,17-;/m1./s1

SMILES isoméricas

C[C@@H]1CC[C@H]([C@@H](C1)C(=O)N2C3=C(C=C(C=C3)OC)N(C2=O)CCN)C(C)C.Cl

CAS alternativo

1008763-54-9

PubChem CID

49787136

Peso molecular

409.95

Propriedades químicas e físicas

• Solubilidade: DMSO : 140 mg/mL (341.51 mM; Need ultrasonic)
• Peso molecular: 409.900 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 409.213 Da
• Monoisotopic Mass: 409.213 Da
• Topological Polar Surface Area: 75.900 Ų
• Heavy Atom Count: 28
• Formal Charge: 0
• Complexity: 553.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 3
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3