D-Leucine - Moligand™,≥99% , CAS No.328-38-1

CAS: 328-38-1 Cat. No.: L110997 Molecular Weight: 131.17 Beilstein Registry Number: 1721721 EC Number: 206-327-7

GRADE & PURITY Moligand™, ≥99%

Synonyms

d-leu42 | D-Leucine, ReagentPlus(R), 99% | (2R)-2-azaniumyl-4-methylpentanoate | H-D-Leu-OH | EINECS 206-327-7 | NCGC00013565-03 | DB01746 | Z850973972 | (R)-Leucine | AKOS015841823 | DLE | NSC 77687 | D-Leu | D-Leuzin | BDBM50463213 | NCGC00163335-02 | B

Storage

Room temperature

Shipped In

Normal

Specifications

Synonyms

d-leu42 | D-Leucine, ReagentPlus(R), 99% | (2R)-2-azaniumyl-4-methylpentanoate | H-D-Leu-OH | EINECS 206-327-7 | NCGC00013565-03 | DB01746 | Z850973972 | (R)-Leucine | AKOS015841823 | DLE | NSC 77687 | D-Leu | D-Leuzin | BDBM50463213 | NCGC00163335-02 | B

Specifications & Purity

Moligand™, ≥99%

Storage

Room temperature

Shipped In

Normal

Grade

Moligand™

Purity

≥99%

Names and Identifiers

• Pubchem Sid: 488189745
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488189745
• Canonical Smiles: CC(C)CC(C(=O)O)N
• IUPAC Name: (2R)-2-amino-4-methylpentanoic acid
• InChIKey: ROHFNLRQFUQHCH-RXMQYKEDSA-N
• INCHI: 1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m1/s1
• Isomeric SMILES: CC(C)C[C@H](C(=O)O)N
• WGK Germany: 3
• RTECS: OH2840000
• Molecular Weight: 131.17
• Beilstein: 1721721
• Reaxy-Rn: 636005
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=636005&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Leucine and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives
• Direct Parent: Leucine and derivatives
• Alternative Parents: D-alpha-amino acids Methyl-branched fatty acids Amino acids Monocarboxylic acids and derivatives Carboxylic acids Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Leucine or derivatives - Alpha-amino acid - D-alpha-amino acid - Branched fatty acid - Methyl-branched fatty acid - Fatty acid - Fatty acyl - Amino acid - Monocarboxylic acid or derivatives - Carboxylic acid - Organic oxide - Organopnictogen compound - Primary amine - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Carbonyl group - Organic oxygen compound - Amine - Organic nitrogen compound - Hydrocarbon derivative - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as leucine and derivatives. These are compounds containing leucine or a derivative thereof resulting from reaction of leucine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
• External Descriptors: Other amino acids

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

SLC7A5 Tchem L-type amino acid transporter 1 (388 Activities)

Discover Target: SLC7A5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LMNA Tbio Prelamin-A/C (36751 Activities)

Discover Target: LMNA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)

Discover Target: RGS4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Plasmodium falciparum (966862 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Impa1 Inositol monophosphatase 1 (16203 Activities)

Discover Target: Impa1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Specific Rotation[α]: -15 ° (C=4, 6mol/L HCl)
• Melt Point(°C): 300°C
• Molecular Weight: 131.170 g/mol
• XLogP3: -1.500
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 131.095 Da
• Monoisotopic Mass: 131.095 Da
• Topological Polar Surface Area: 63.300 Ų
• Heavy Atom Count: 9
• Formal Charge: 0
• Complexity: 101.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

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2. Zhiyang Xu, Yinzhou Yan, Xingyuan Wang, Xiaolei Wang, Zhixiang Zhou, Xi Yang, Tianrui Zhai.  (2023)  Determination of Enantiomeric Excess by Optofluidic Microlaser near Exceptional Point.  Advanced Science,      [PMID:38072636] [10.1002/advs.202308362]

3. Weijie Fu, Kai Zhang, Xiaohua Zhang, Guorong Fan, Zongde Wang, Shangxing Chen, Yangping Wen, Peng Wang.  (2022)  Synthesis of transition metal sulfide functionalized hierarchically porous carbons and their application as colorimetric-electrochemical dual-mode nanozyme sensing platform for dopamine.  ELECTROCHIMICA ACTA,      [PMID:] [10.1016/j.electacta.2022.141535]

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10. Chong Liu, Xiaoxue Han, Qing Zhang, Zhuojia Shi, Yuqing Zhang, Yu Chen.  (2024)  Green low-melting mixture solvents/ionic liquids-based carbon materials and lithium-ion batteries recycling leachate unexpectedly cause water pollution from dissolved organic matter.  JOURNAL OF THE INDIAN CHEMICAL SOCIETY,      [PMID:] [10.1016/j.jics.2024.101458]

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