DDX3-IN-2 - ≥99% , CAS No.1919828-81-1

CAS: 1919828-81-1 Cat. No.: D650616 Fórmula: C₂₀H₂₃N₅O Peso molecular: 349.43

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

DDX3-IN-2 is an active DEADbox polypeptide 3 ( DDX3 ) inhibitor with an IC 50 value of 0.3 μM. DDX3-IN-2 shows a broad spectrum of antiviral activity. DDX3-IN-2 has the potential to overcome HIV resistance

In Vitro

DDX3-IN-2 behaves as a competitive inhibitor with respect to the RNA substrate, which can be seen by the decrease in its inhibition potency as a function of increasing RNA substrate concentrations. DDX3-IN-2 is found to be completely inactive against the ATPase of DDX3, DDX1 helicase, and DENV NS3 helicase. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DDX3-IN-2 (20 mg/kg; tail vein injection) possesses excellent biocompatibility, and Wistar rats shows a good tolerance to the dose of 20 mg/kg . DDX3-IN-2 (10 mg/kg; i.v. bolus injection; 0~25 hours) rapidly eliminates the half-life elimination and the plasmatic clearance values . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Wistar rats Dosage: Tail vein injection Administration: 20 mg/kg Result: Possessed excellent biocompatibility, and Wistar rats showed a good tolerance to the dose of 20 mg/kg. Animal Model: Rats Dosage: I.v. bolus injection (Pharmacokinetic Analysis) Administration: 10 mg/kg; 0~25 hours Result: Rapidly eliminated the half-life elimination and the plasmatic clearance values.

Form:Solid

IC50& Target:HIV

Specifications

Especificações e pureza

≥99%

Mecanismos bioquímicos e fisiológicos

DDX3-IN-2 is an active DEADbox polypeptide 3 ( DDX3 ) inhibitor with an IC 50 value of 0.3 μM. DDX3-IN-2 shows a broad spectrum of antiviral activity. DDX3-IN-2 has the potential to overcome HIV resistance.

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

INHIBITOR

Pureza

≥99%

Nomes e identificadores

• Peso molecular: 349.43

Propriedades químicas e físicas

• Solubilidade: DMSO : 100 mg/mL (286.18 mM; Need ultrasonic)