Desonide - Moligand™, 10mM in DMSO , Glucocorticoid receptor agonist, CAS No.638-94-8, Glucocorticoid receptor agonist

CAS: 638-94-8 Cat. No.: D408853 Fórmula: C₂₄H₃₂O₆ Peso molecular: 416.51 Número CE: 211-351-6

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

(11β,​16α)​-11,​21-​dihydroxy-​16,​17-​[(1-​methylethylidene)​bis(oxy)​]​-pregna-​1,​4-​diene-​3,​20-​dione

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

Desonide Desonide is a low potency topical corticosteroid.
In vitro

In vivo

Cell Data

cell lines：MCF-7, SW620, K562, SK-MEL-5 and A375 cancer cell lines

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

(11β,​16α)​-11,​21-​dihydroxy-​16,​17-​[(1-​methylethylidene)​bis(oxy)​]​-pregna-​1,​4-​diene-​3,​20-​dione

Especificações e pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos e fisiológicos

Desonide is a low potency topical corticosteroid.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Tipo de ação

AGONIST

Mecanismo de ação

Glucocorticoid receptor agonist

Propriedades do produto

• ALogP: 2.7

Nomes e identificadores

• SMILES isoméricas: C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1C[C@@H]4[C@]2(OC(O4)(C)C)C(=O)CO)CCC5=CC(=O)C=C[C@]35C)O
• Peso molecular: 416.51
• Reaxy-Rn: 356665
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=356665&ln=

Propriedades químicas e físicas

• Rotação específica [α]: 132° (C=0.5,DMF)
• Ponto de fusão (°C): 272-274°C

Referências

1. Liheng Gao, Xingxing Liu, Wenshuo Zhao, Chaojin Li, Fujun Wang, Jing Gao, Xinqin Liao, Lei Wei, Hao Wu, Yuanjin Zheng, Lu Wang.  (2022)  Extracellular-matrix-mimicked 3D nanofiber and hydrogel interpenetrated wound dressing with a dynamic autoimmune-derived healing regulation ability based on wound exudate.  Biofabrication,  15  (1): (015021).  [PMID:36579621] [10.1088/1758-5090/acaa01]

2. Yangjie LI, Jiaying HUANG, Jihui FANG, Zhiye HUANG.  (2022)  [Fast screening and confirmation of 73 common prohibited compounds in cosmetics by ultra performance liquid chromatography-quadrupole-time-of-flight high resolution mass spectrometry]..  Chinese Journal of Chromatography,  40  (5): (433-442).  [PMID:35478002] [10.3724/sp.j.1123.2021.09010]

3. Yanxia Li, Xiaoman Chen, Ling Xia, Xiaohua Xiao, Gongke Li.  (2019)  Magnetic metal-organic frameworks-101 functionalized with graphite-like carbon nitride for the efficient enrichment of glucocorticoids in cosmetics.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:31353072] [10.1016/j.chroma.2019.460382]