DPH - ≥98% , CAS No.484049-04-9

CAS: 484049-04-9 Cat. No.: D126816 Fórmula: C₁₈H₁₃FN₄O₂ Peso molecular: 336.32

GRADE & PURITY ≥98%

Synonyms

DTXSID30349772 | 5-[3-(4-fluorophenyl)-1-phenyl-4-pyrazolyl]imidazolidine-2,4-dione | SMR000041163 | 5-[3-(4-fluorophenyl)-1-phenyl-1h-pyrazol-4-yl]-2,4-imidazolidinedione | 5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)imidazolidine-2,4-dione | 5-[3-(4-

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

DPH
DPH may be used in c-Abl tyrosine kinase-mediated cell signaling studies.

Specifications

Sinónimos

DTXSID30349772 | 5-[3-(4-fluorophenyl)-1-phenyl-4-pyrazolyl]imidazolidine-2,4-dione | SMR000041163 | 5-[3-(4-fluorophenyl)-1-phenyl-1h-pyrazol-4-yl]-2,4-imidazolidinedione | 5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)imidazolidine-2,4-dione | 5-[3-(4-

Especificações e pureza

≥98%

Mecanismos bioquímicos e fisiológicos

DPH binds and changes the conformation of the c-Abl tyrosine kinase myristoyl-binding site. Shows potent enzymatic and cellular activity that stimulates c-Abl activation. DPH is a potent cell-permeable c-Abl activator. DPH binds to the myristoyl binding s

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

ACTIVATOR

Pureza

≥98%

Nomes e identificadores

• Pubchem Sid: 504759797
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504759797
• Sorrisos canónicos: C1=CC=C(C=C1)N2C=C(C(=N2)C3=CC=C(C=C3)F)C4C(=O)NC(=O)N4
• IUPAC Name: 5-[3-(4-fluorophenyl)-1-phenylpyrazol-4-yl]imidazolidine-2,4-dione
• InChIKey: MPQWYPLPWGUMJE-UHFFFAOYSA-N
• INCHI: 1S/C18H13FN4O2/c19-12-8-6-11(7-9-12)15-14(16-17(24)21-18(25)20-16)10-23(22-15)13-4-2-1-3-5-13/h1-10,16H,(H2,20,21,24,25)
• SMILES isoméricas: C1=CC=C(C=C1)N2C=C(C(=N2)C3=CC=C(C=C3)F)C4C(=O)NC(=O)N4
• WGK Alemanha: 3
• Peso molecular: 336.32
• Reaxy-Rn: 21813460
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=21813460&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Azoles
      • Subclass Pyrazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Azoles
• Subclass: Pyrazoles
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylpyrazoles
• Alternative Parents: Alpha amino acids and derivatives 5-monosubstituted hydantoins N-acyl ureas Fluorobenzenes Aryl fluorides Heteroaromatic compounds Dicarboximides Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organofluorides Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Hydantoin - Phenylpyrazole - Alpha-amino acid or derivatives - 5-monosubstituted hydantoin - Fluorobenzene - Halobenzene - Ureide - N-acyl urea - Aryl fluoride - Aryl halide - Monocyclic benzene moiety - Benzenoid - Imidazolidinone - Dicarboximide - Heteroaromatic compound - Imidazolidine - Carbonic acid derivative - Urea - Azacycle - Carboxylic acid derivative - Organooxygen compound - Organic oxygen compound - Hydrocarbon derivative - Organic nitrogen compound - Carbonyl group - Organic oxide - Organopnictogen compound - Organohalogen compound - Organofluoride - Organonitrogen compound - Aromatic heteromonocyclic compound
• Descrição: This compound belongs to the class of organic compounds known as phenylpyrazoles. These are compounds containing a phenylpyrazole skeleton, which consists of a pyrazole bound to a phenyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Alvos associados (humanos)

ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)

Discover Target: ABL1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

VDR Tclin Vitamin D receptor (26531 Activities)

Discover Target: VDR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PLK1 Tchem Serine/threonine-protein kinase PLK1 (28605 Activities)

Discover Target: PLK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)

Discover Target: KDM4A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GMNN Tbio Geminin (128009 Activities)

Discover Target: GMNN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 Activities)

Discover Target: GLS

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Alvos associados (não humanos)

Plasmodium falciparum (966862 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ddn Putative uncharacterized protein (49 Activities)

Discover Target: ddn

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de ação

Propriedades químicas e físicas

• Solubilidade: DMSO
• Peso molecular: 336.300 g/mol
• XLogP3: 2.400
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 336.102 Da
• Monoisotopic Mass: 336.102 Da
• Topological Polar Surface Area: 76.000 Ų
• Heavy Atom Count: 25
• Formal Charge: 0
• Complexity: 517.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referências

1. Yang Xiaoling, Zhao Shunan, Deng Yong, Xu Weidong, Wang Zonghan, Wang Wenjun, Lv Ruiling, Liu Donghong.  (2023)  Antibacterial activity and mechanisms of α-terpineol against foodborne pathogenic bacteria.  APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,      [PMID:37682300] [10.1007/s00253-023-12737-4]

2. Xinyue Ye, Jian Wang, Pengfei Xu, Xiaoqian Yang, Qixue Shi, Genyan Liu, Zhaoshi Bai, Changlin Zhou, Lingman Ma.  (2023)  Peptide MSI-1 inhibited MCR-1 and regulated outer membrane vesicles to combat immune evasion of Escherichia coli.  Microbial Biotechnology,      [PMID:37329166] [10.1111/1751-7915.14297]

3. Yang Gao, Ya Sun, Guangli Liao, Hailong Zhang, Qingzhi Long.  (2021)  DSPE-PEG polymers for improving pulmonary absorption of poorly absorbed macromolecules in rats and relative mechanism.  DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY,      [PMID:33502913] [10.1080/03639045.2021.1879837]

4. Guosong Xin, Miao Yu, Yang Hu, Shiyong Gao, Zheng Qi, Yuan Sun, Wenjing Yu, Jiaxin He, Yubin Ji.  (2020)  Effect of lycorine on the structure and function of hepatoma cell membrane in vitro and in vivo.  BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT,      [PMID:] [10.1080/13102818.2020.1719019]

5. Rui Wang, Zhaoyue Dong, Xiaolong Zhang, Jingxin Mao, Fancheng Meng, Xiaozhong Lan, Zhihua Liao, Min Chen.  (2019)  Evaluation of the Liver Toxicity of Pterocephalus hookeri Extract via Triggering Necrosis.  Toxins,  11  (3): (142).  [PMID:30832306] [10.3390/toxins11030142]

6. Ou Yun, Zhi-Wei Liu, Xin-An Zeng, Zhong Han.  (2016)  Salmonella typhimurium resistance on pulsed electric fields associated with membrane fluidity and gene regulation.  Innovative Food Science & Emerging Technologies,      [PMID:] [10.1016/j.ifset.2016.06.013]

7. Hong Zhuang, Xiaoliang Zhang, Sijia Wu, Chen Mao, Yaxi Dai, Pang Yong, Xiaodi Niu.  (2024)  Study transport of hesperidin based on the DPPC lipid model and the BSA transport model.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:38513316] [10.1016/j.saa.2024.124172]

8. Sijia Wu, Ping Jiang, Xiaoliang Zhang, Chen Mao, Yaxi Dai, Hong Zhuang, Yong Pang.  (2024)  Understanding the Transepithelial Transport and Transbilayer Diffusion of the Antihypertensive Peptide Asn-Cys-Trp: Insights from Caco-2 Cell Monolayers and the DPPC Model Membrane.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:38639269] [10.1021/acs.jafc.4c00155]

9. Meng Jin, Ge Gao, Zeyu Liu, Xiao Meng, Haiyan Wei, Wenwen Chen, Hui Pan, Mengping Zhang, Qiang Jia, Cuijuan Wang.  (2025)  Rapid detection of diphenhydramine in children’s cosmetics using SERS-active gold hedgehog particles/MOF-801 deposited on cellulose nanofibrils films.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2025.138883]