EGFR-IN-60 , CAS No.2699877-43-3

CAS: 2699877-43-3 Cat. No.: E1418547 Fórmula: C₂₈H₂₈Cl₂N₆O Peso molecular: 535.47

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

EGFR-IN-60 (Compound 7d) shows obvious inhibition of EGFR WT , EGFR T790M , EGFR L858R and JAK3 with IC 50 s of 83, 26, 53, and 69 nM, respectively. EGFR-IN-60 potently inhibits the growth of H1975 cells harboring EGFR T790M mutation (IC 50 =1.32 µM) over A431 cells overexpressing EGFR WT (IC 50 =4.96 µM). EGFR-IN-60 exhibits good oral absorption, potent and safe antitumor activity. EGFR-IN-60 induces cell death through apoptosis supported by increased Bax/Bcl-2 ratio.

Specifications

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

ACTIVATOR

Nomes e identificadores

Peso molecular

535.47

Perguntas frequentes

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2699877-43-3, the molecular formula is C28H28Cl2N6O, and the molecular weight is 535.47 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.