Butylhydrazine Dihydrochloride: Properties & Lab Use FAQ

Butylhydrazine dihydrochloride is a stable, salt-form hydrazine derivative used as a versatile building block in organic synthesis and pharmaceutical research.

Chemical Name

Butylhydrazine dihydrochloride

SKU

B944239

Compound Class

Alkylhydrazine salt (dihydrochloride form)

Physical Form

Solid (salt form), typically white to off-white powder

Solubility

Soluble in water and polar protic solvents; limited solubility in non-polar organic solvents

Storage Condition

Store in a cool, dry place; keep tightly sealed away from moisture and oxidising agents

What Is Butylhydrazine Dihydrochloride?

Butylhydrazine dihydrochloride is the dihydrochloride salt of butylhydrazine, an aliphatic hydrazine derivative in which a butyl group is attached to one nitrogen of the hydrazine (H₂N–NH₂) core. Converting the free base to the dihydrochloride salt significantly improves chemical stability, handling safety, and shelf life compared with the free hydrazine form. As a result, it is the preferred form supplied for laboratory use.

In research settings, alkylhydrazine salts such as this compound serve as nucleophilic nitrogen-containing building blocks. They participate in condensation reactions with carbonyl compounds (ketones and aldehydes) to form hydrazones, and they are widely used in the synthesis of heterocyclic scaffolds including pyrazoles, triazoles, and related nitrogen-rich ring systems of pharmaceutical relevance.

Handling, Safety, and Storage Guidelines

Hydrazine derivatives as a chemical class carry inherent hazards, including potential toxicity and irritant properties. Researchers should consult the Safety Data Sheet (SDS) for butylhydrazine dihydrochloride (SKU B944239) before use and adhere to all institutional chemical safety protocols.

• Personal Protective Equipment (PPE): Wear appropriate gloves, lab coat, and eye protection when handling.
• Ventilation: Handle in a well-ventilated area or fume hood to minimise inhalation exposure.
• Storage: Store in a cool, dry, well-ventilated location in a tightly closed container, isolated from oxidising agents, strong acids, and moisture.
• Waste Disposal: Dispose of in accordance with local regulations governing hazardous chemical waste.

Because the compound is supplied as a salt, it is appreciably more stable than the corresponding free-base hydrazine; however, standard precautions for reactive nitrogen compounds remain applicable.

Typical Laboratory Applications

Butylhydrazine dihydrochloride finds use across several areas of synthetic and medicinal chemistry:

• Hydrazone Formation: Reaction with aldehydes and ketones produces hydrazones, which are intermediates in drug synthesis, prodrug design, and analytical chemistry (e.g., carbonyl detection).
• Heterocycle Synthesis: The compound serves as a precursor for pyrazole, pyridazine, and triazole ring construction, scaffolds that appear frequently in active pharmaceutical ingredients (APIs) and agrochemicals.
• Structure–Activity Relationship (SAR) Studies: The n-butyl substituent provides a defined lipophilic element, making butylhydrazine dihydrochloride useful for exploring how alkyl chain length affects biological activity within a compound series.
• Coordination Chemistry: Hydrazine derivatives can act as ligands for metal complexes, relevant to catalysis and materials research.

Researchers should optimise reaction conditions (base equivalents to liberate the free hydrazine in situ, solvent, temperature) according to the specific transformation intended.

Solubility and Reconstitution Recommendations

As a dihydrochloride salt, butylhydrazine dihydrochloride is appreciably soluble in water and polar protic solvents such as methanol and ethanol. This facilitates preparation of aqueous stock solutions for biological assay workflows.

For organic reactions requiring the free-base form, the salt can be treated with an appropriate base (e.g., triethylamine or sodium carbonate) in the reaction mixture to liberate the neutral butylhydrazine in situ. Solubility in aprotic organic solvents such as DMF or DMSO is generally limited and should be empirically verified for the specific application.

Practical tips:

• Prepare stock solutions fresh or store under inert atmosphere to prevent oxidation.
• Filter solutions if particulates are observed prior to use in sensitive assays.
• Record actual weighed mass and calculated molarity for reproducibility.

Ordering and Product Specifications

Butylhydrazine dihydrochloride is available from Aladdin Scientific under SKU B944239. When placing an order, researchers and procurement teams should note:

• Purity: Confirm the certificate of analysis (CoA) for the specific lot to verify purity grade prior to use in quantitative or regulatory-relevant experiments.
• Pack sizes: Contact Aladdin Scientific or visit the product page for available quantities.
• Documentation: SDS, CoA, and structural confirmation data (e.g., NMR, HPLC) are available upon request or via the product page.
• Regulatory compliance: Hydrazine derivatives may be subject to transport restrictions in certain jurisdictions; confirm shipping regulations with your local Aladdin representative before ordering.

For technical questions about this product, contact Aladdin Scientific's technical support team via the website or your regional sales contact.

Frequently asked questions

What is butylhydrazine dihydrochloride used for in the laboratory?

Butylhydrazine dihydrochloride is primarily used as a synthetic building block in organic and medicinal chemistry. Key applications include hydrazone formation via condensation with aldehydes or ketones, and as a precursor for heterocyclic ring synthesis, particularly pyrazoles and triazoles relevant to pharmaceutical and agrochemical research.

Why is butylhydrazine supplied as the dihydrochloride salt rather than the free base?

The dihydrochloride salt form is significantly more chemically stable and easier to handle than the corresponding free-base hydrazine, which is volatile, highly reactive, and poses greater safety concerns. The salt form has improved shelf life, lower volatility, and is more convenient for accurate weighing and long-term storage under standard laboratory conditions.

How should I dissolve butylhydrazine dihydrochloride for use in reactions?

For aqueous or protic solvent systems, dissolve the salt directly in water, methanol, or ethanol; it is readily soluble in these solvents. For reactions requiring the free-base form in organic media, treat the salt in situ with a suitable base such as triethylamine or sodium carbonate to liberate the neutral hydrazine. Always verify solubility empirically for your specific solvent and concentration.

What safety precautions should be taken when handling this compound?

Butylhydrazine dihydrochloride should be handled with appropriate PPE including gloves, lab coat, and eye protection. Work in a fume hood or well-ventilated area to avoid inhalation. Store tightly sealed away from oxidising agents and moisture. Consult the current SDS for SKU B944239 for full hazard and first-aid information before use.

How can I confirm the identity and purity of the butylhydrazine dihydrochloride I receive?

Request the Certificate of Analysis (CoA) for your specific lot from Aladdin Scientific. The CoA typically includes identity confirmation by spectroscopic methods (e.g., NMR) and purity data (e.g., HPLC or titration). Contact Aladdin Scientific's technical support or visit the product page for SKU B944239 to access lot-specific documentation.

References

1. March, J. Advanced Organic Chemistry: Reactions, Mechanisms, and Structure. Wiley-Interscience. General reference for hydrazone and heterocycle formation reactions.
2. Küenburg, B. et al. Synthesis of pyrazoles and related nitrogen heterocycles from hydrazine derivatives: a review of synthetic strategies. General textbook-level reference.
3. Aladdin Scientific. Product Page: Butylhydrazine dihydrochloride, SKU B944239. Aladdin Scientific Co., Ltd.

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.