Flutamide - Moligand™, 10mM in DMSO , Antagonist of Androgen receptor, CAS No.13311-84-7, Antagonist of Androgen receptor

CAS: 13311-84-7 Cat. No.: F408131 Fórmula: C₁₁H₁₁F₃N₂O₃ Peso molecular: 276.22 Número CE: 236-341-9

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

SCH-13521 | 2-​methyl-​N-​[4-​nitro-​3-​(trifluoromethyl)​phenyl]​-propanamide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

Flutamide Flutamide (SCH-13521) is an antiandrogen drug, with its active metablolite binding at androgen receptor with K i values of 55 nM, and primarily used to treat prostate cancer.
In vitro

Flutamide (Eulexin) is an antiandrogen drug. Flutamide-OH, the active metabolite of flutamide, directly binds at rat anterior pituitary androgen receptor with K_i values of 55 nM. Flutamide does not affect the proliferation of an androgen-sensitive clone of the mouse mammary carcinoma Shionogi SC-l 15 cells in culture, shows only antiandrogenic effect, but not androgenic effect. Flutamide provides treatment for prostate cancer when used along with leuprolide.

In vivo

Flutamide causes a markedly reduction in rat ventral prostate weight from 319 mg to 245 mg. A combination of flutamide and LHRH agonist induces an additive effect with a decrease in prostate weight to 101 mg, and an marked drop in prostatic ODC activity.
Cell Data

cell lines：

Concentrations：~1 μM

Incubation Time：40 days

Powder Purity:≥99%

Specifications

Sinónimos

SCH-13521 | 2-​methyl-​N-​[4-​nitro-​3-​(trifluoromethyl)​phenyl]​-propanamide

Especificações e pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos e fisiológicos

Flutamide (SCH-13521) is an antiandrogen drug, with its active metablolite binding at androgen receptor with K_i values of 55 nM, and primarily used to treat prostate cancer.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Tipo de ação

ANTAGONIST

Mecanismo de ação

Antagonist of Androgen receptor

Nomes e identificadores

• SMILES isoméricas: CC(C)C(=O)NC1=CC(=C(C=C1)[N+](=O)[O-])C(F)(F)F
• WGK Alemanha: 3
• RTECS: UG5700000
• Peso molecular: 276.22
• Reaxy-Rn: 2157663
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2157663&ln=

Alvos associados (humanos)

CYP1A2 Tchem Cytochrome P450 1A2 (1 Activities)

Discover Target: CYP1A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AR Tclin Androgen receptor (1 Activities)

Discover Target: AR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AADAC Tchem Arylacetamide deacetylase (1 Activities)

Discover Target: AADAC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propriedades químicas e físicas

• Ponto de fusão (°C): 112 °C

Referências

1. Jiao Sha, Kaibo Hu, Tingting Li, Zidan Cao, Yameng Wan, Renren Sun, Haixia He, Gaoliang Jiang, Yu Li, Tao Li, Baozeng Ren.  (2021)  Solubility determination, model correlation, solvent effect, molecular simulation and thermodynamic properties of flutamide in eleven pure solvents at different temperatures.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2021.115559]

2. Junrong Lin, Zetao Dang, Yijing Du, Yanli Gao, Jia Li, Yuewei Zhang, Shoujun Zhu.  (2025)  Site-specific mutated albumin for covalently targeting NIR-II dye enables noninvasive imaging of blood-testis barrier integrity.  Cell Reports Physical Science,      [PMID:] [10.1016/j.xcrp.2025.102499]