HDSF - ≥96% , CAS No.86855-26-7

CAS: 86855-26-7 Cat. No.: H331899 Fórmula: C₁₆H₃₃FO₂S Peso molecular: 308.5 Beilstein Registry Number: 4411921

GRADE & PURITY ≥96%

Synonyms

palmitylsulphonyl fluoride | 1-Hexadecanesulfonylfluoride | 1-Hexadecanesulfonyl fluoride | 1-HEXADECYLSULFONYL FLUORIDE | SYL-374 | Hexadecanesulfonyl fluoride | HY-125967 | AM 374 | BDBM50396293 | CHEBI:43275 | hexadecane-1-sulfonyl fluoride | Hexadecyl

Storage

Armazenar a -20°C

Shipped In

Arca de gelo + almofadas de gelo

Visão geral

Descrição do produto:

O HDSF é um agente modificador específico da serina, direcionado para o local ativo, que actua como um inibidor irreversível da Cln1 (palmitoil-proteína tioesterase-1 (Ki = 125 μM)). O HDSF inibe a lipase, mas não a atividade da fosfolipase C no sobrenadante da cultura de Pseudomonas aeruginosa e a atividade da fosfolipase A em E. coli.

Specifications

Sinónimos

palmitylsulphonyl fluoride | 1-Hexadecanesulfonylfluoride | 1-Hexadecanesulfonyl fluoride | 1-HEXADECYLSULFONYL FLUORIDE | SYL-374 | Hexadecanesulfonyl fluoride | HY-125967 | AM 374 | BDBM50396293 | CHEBI:43275 | hexadecane-1-sulfonyl fluoride | Hexadecyl

Especificações e pureza

≥96%

Condições de armazenamento de armazenamento

Armazenar a -20°C

Enviado em

Arca de gelo + almofadas de gelo

Tipo de ação

INHIBITOR

Pureza

≥96%

Propriedades do produto

Dados Ki

Cln1: Ki= 125 μM

Nomes e identificadores

Pubchem Sid

488179777

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/488179777

Sorrisos canónicos

CCCCCCCCCCCCCCCCS(=O)(=O)F

IUPAC Name

hexadecane-1-sulfonyl fluoride

InChIKey

QIVFMUVBIHIZAM-UHFFFAOYSA-N

INCHI

1S/C16H33FO2S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20(17,18)19/h2-16H2,1H3

SMILES isoméricas

CCCCCCCCCCCCCCCCS(=O)(=O)F

Peso molecular

308.5

Beilstein

4411921

Reaxy-Rn

4411921

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4411921&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organohalogen compounds
    • Classe Sulfonyl halides
      • Subclass Sulfonyl fluorides

• Kingdom: Organic compounds
• Superclass: Organohalogen compounds
• Classe: Sulfonyl halides
• Subclass: Sulfonyl fluorides
• Intermediate Tree Nodes: Not available
• Direct Parent: Sulfonyl fluorides
• Alternative Parents: Sulfonyls Organosulfonic acids and derivatives Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Sulfonyl - Sulfonyl fluoride - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organosulfur compound - Aliphatic acyclic compound
• Descrição: This compound belongs to the class of organic compounds known as sulfonyl fluorides. These are compounds containing a sulfonyl (R-S(=O)2-R') functional group singly bonded to a fluorine atom.
• External Descriptors: acyl fluoride

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Alvos associados (humanos)

LPL Tchem Lipoprotein lipase (101 Activities)

Discover Target: LPL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MGLL Tchem Monoglyceride lipase (1909 Activities)

Discover Target: MGLL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Alvos associados (não humanos)

Faah Anandamide amidohydrolase (3907 Activities)

Discover Target: Faah

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de ação

Propriedades químicas e físicas

• Solubilidade: Soluble in DMSO (10 mg/ml).
• Índice de refração: n20D1.45 (Predicted)
• Ponto de inflamação (°C): 188.6ºC
• Ponto de ebulição (°C): 388.3ºC at 760 mmHg
• Peso molecular: 308.500 g/mol
• XLogP3: 7.900
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 15
• Exact Mass: 308.219 Da
• Monoisotopic Mass: 308.219 Da
• Topological Polar Surface Area: 42.500 Ų
• Heavy Atom Count: 20
• Formal Charge: 0
• Complexity: 283.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1