Ibrolipim - ≥95% , CAS No.133208-93-2

CAS: 133208-93-2 Cat. No.: L339156 Fórmula: C₁₉H₂₀BrN₂O₄P Peso molecular: 451.25 Número CE: 634-329-1

GRADE & PURITY ≥95%

Synonyms

DMAA (Antiparkinson Agent) | Ibrolipim [USAN] | J-006332 | Lipoprotein Lipase Activator | N-(4-bromo-2-cyanophenyl)-4-(diethoxyphosphorylmethyl)benzamide | Q5984863 | 2-Methyl-1,4-naphthochinon | HY-117549 | NO-1886 | AKOS005067076 | Diethyl 4-((4-bromo-2

Storage

Armazenar a -20°C

Shipped In

Arca de gelo + almofadas de gelo

Visão geral

O Lipoprotein Lipase Activator é um derivado de benzilfosfonato permeável às células que induz seletivamente os níveis de ARNm e de proteína da lipoproteína lipase (LPL), mas não apresenta actividades agonísticas PPARα ou PPARγ. O Lipoprotein Lipase Activator reduz os níveis séricos de lípidos e os triglicéridos plasmáticos com elevação concomitante do colesterol de lipoproteínas de alta densidade (HDL-C) em modelos animais. O Lipoprotein Lipase Activator também induz enzimas relacionadas com a oxidação de ácidos gordos, reduz os ácidos gordos livres (AGL) e minimiza a acumulação de gordura. Também foi relatado que suprime os níveis plasmáticos de TNF-a e COX-2 e apresenta propriedades anti-tumorais.

Specifications

Sinónimos

DMAA (Antiparkinson Agent) | Ibrolipim [USAN] | J-006332 | Lipoprotein Lipase Activator | N-(4-bromo-2-cyanophenyl)-4-(diethoxyphosphorylmethyl)benzamide | Q5984863 | 2-Methyl-1,4-naphthochinon | HY-117549 | NO-1886 | AKOS005067076 | Diethyl 4-((4-bromo-2

Especificações e pureza

≥95%

Mecanismos bioquímicos e fisiológicos

Ativador da lipase lipoproteica. A sobreexpressão da lipoproteína lipase em coelhos transgénicos leva a um aumento do LDL pequeno e denso no plasma e promove a aterosclerose. A administração a longo prazo de NO-1886 protege contra o desenvolvimento de ate

Condições de armazenamento de armazenamento

Armazenar a -20°C

Enviado em

Arca de gelo + almofadas de gelo

Tipo de ação

ACTIVATOR

Pureza

≥95%

Propriedades do produto

pKa

pKa: 11.51 (Predicted)

Nomes e identificadores

Pubchem Sid

528764933

Sorrisos canónicos

CCOP(=O)(CC1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)Br)C#N)OCC

IUPAC Name

N-(4-bromo-2-cyanophenyl)-4-(diethoxyphosphorylmethyl)benzamide

InChIKey

KPRTURMJVWXURQ-UHFFFAOYSA-N

INCHI

1S/C19H20BrN2O4P/c1-3-25-27(24,26-4-2)13-14-5-7-15(8-6-14)19(23)22-18-10-9-17(20)11-16(18)12-21/h5-11H,3-4,13H2,1-2H3,(H,22,23)

SMILES isoméricas

CCOP(=O)(CC1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)Br)C#N)OCC

WGK Alemanha

3

Peso molecular

451.25

Reaxy-Rn

7497256

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7497256&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Benzene and substituted derivatives
      • Subclass Anilides
        • Level5 Aromatic anilides
          • Level6 Benzanilides

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Benzene and substituted derivatives
• Subclass: Anilides
• Intermediate Tree Nodes: Aromatic anilides
• Direct Parent: Benzanilides
• Alternative Parents: Benzamides Benzoyl derivatives Benzonitriles Dialkyl alkylphosphonates Bromobenzenes Phosphonic acid esters Aryl bromides Secondary carboxylic acid amides Nitriles Organopnictogen compounds Organophosphorus compounds Organooxygen compounds Organobromides Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Benzanilide - Benzamide - Benzoic acid or derivatives - Benzonitrile - Benzoyl - Dialkyl alkylphosphonate - Bromobenzene - Halobenzene - Phosphonic acid diester - Phosphonic acid ester - Aryl bromide - Aryl halide - Organophosphonic acid derivative - Secondary carboxylic acid amide - Carboxamide group - Carboxylic acid derivative - Nitrile - Carbonitrile - Hydrocarbon derivative - Organohalogen compound - Organobromide - Organonitrogen compound - Organooxygen compound - Organopnictogen compound - Organic oxygen compound - Organophosphorus compound - Organic nitrogen compound - Organic oxide - Aromatic homomonocyclic compound
• Descrição: This compound belongs to the class of organic compounds known as benzanilides. These are aromatic compounds containing an anilide group in which the carboxamide group is substituted with a benzene ring. They have the general structure RNC(=O)R', where R,R'= benzene.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Alvos associados (humanos)

LPL Tchem Lipoprotein lipase (101 Activities)

Discover Target: LPL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RPTEC (172 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Alvos associados (não humanos)

Rattus norvegicus (775804 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de ação

Propriedades químicas e físicas

• Solubilidade: Soluble in DMSO (≥20 mg/ml).
• Índice de refração: n20D1.59 (Predicted)
• Ponto de ebulição (°C): 512.47° C at 760 mmHg (Predicted)
• Ponto de fusão (°C): 90.27° C (Predicted)
• Peso molecular: 451.200 g/mol
• XLogP3: 3.500
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 8
• Exact Mass: 450.034 Da
• Monoisotopic Mass: 450.034 Da
• Topological Polar Surface Area: 88.400 Ų
• Heavy Atom Count: 27
• Formal Charge: 0
• Complexity: 576.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1