Iguratimod - Moligand™, 10mM in DMSO , Cyclooxygenase-2 inhibitor, CAS No.123663-49-0, Cyclooxygenase-2 inhibitor

CAS: 123663-49-0 Cat. No.: I421025 Molecular Weight: 374.37 EC Number: 808-127-0

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Careram | N-[7-(methanesulfonamido)-4-oxo-6-phenoxy-chromen-3-yl]formamide;Iguratimod | SR-01000945251 | BDBM50458537 | C17H14N2O6S | D01146 | Z2681891323 | CCG-268349 | N-(3-Formamido-4-oxo-6-phenoxy-4H-chromen-7-yl)methanesulfonamide | 3-Formylamino-7-m

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Iguratimod(T-614) is a selective inhibitor of cyclo-oxygenase-2 (COX-2), and inhibits the production of interleukin-1 (IL-1), IL-6, IL-8 and tumour necrosis factor.

Specifications

Synonyms

Careram | N-[7-(methanesulfonamido)-4-oxo-6-phenoxy-chromen-3-yl]formamide;Iguratimod | SR-01000945251 | BDBM50458537 | C17H14N2O6S | D01146 | Z2681891323 | CCG-268349 | N-(3-Formamido-4-oxo-6-phenoxy-4H-chromen-7-yl)methanesulfonamide | 3-Formylamino-7-m

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Iguratimod(T 614) is one of a series of 4H-1-benzopyran-4-ones which has potent anti-inflammatory, analgesic and antipyretic activity.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Cyclooxygenase-2 inhibitor

Product Properties

• ALogP: 1.4

Names and Identifiers

• Canonical Smiles: CS(=O)(=O)NC1=C(C=C2C(=C1)OC=C(C2=O)NC=O)OC3=CC=CC=C3
• IUPAC Name: N-[7-(methanesulfonamido)-4-oxo-6-phenoxychromen-3-yl]formamide
• InChIKey: ANMATWQYLIFGOK-UHFFFAOYSA-N
• INCHI: 1S/C17H14N2O6S/c1-26(22,23)19-13-8-15-12(17(21)14(9-24-15)18-10-20)7-16(13)25-11-5-3-2-4-6-11/h2-10,19H,1H3,(H,18,20)
• Isomeric SMILES: CS(=O)(=O)NC1=C(C=C2C(=C1)OC=C(C2=O)NC=O)OC3=CC=CC=C3
• Molecular Weight: 374.37
• Reaxy-Rn: 8640145
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8640145&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Benzopyrans
      • Subclass 1-benzopyrans

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Benzopyrans
• Subclass: 1-benzopyrans
• Intermediate Tree Nodes: Not available
• Direct Parent: Chromones
• Alternative Parents: Diarylethers Sulfanilides Phenoxy compounds Phenol ethers N-arylamides Pyranones and derivatives Organosulfonamides Organic sulfonamides Aminosulfonyl compounds Heteroaromatic compounds Secondary carboxylic acid amides Oxacyclic compounds Hydrocarbon derivatives Organic oxides Carbonyl compounds Organopnictogen compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Diaryl ether - Chromone - Sulfanilide - N-arylamide - Phenol ether - Phenoxy compound - Pyranone - Benzenoid - Pyran - Organosulfonic acid amide - Organic sulfonic acid amide - Monocyclic benzene moiety - Heteroaromatic compound - Aminosulfonyl compound - Sulfonyl - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Secondary carboxylic acid amide - Carboxamide group - Carboxylic acid derivative - Ether - Oxacycle - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organosulfur compound - Hydrocarbon derivative - Carbonyl group - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as chromones. These are compounds containing a benzopyran-4-one moiety.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

F2 Tclin Thrombin (11687 Activities)

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ESR1 Tclin Estrogen receptor alpha (17718 Activities)

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PGR Tclin Progesterone receptor (8562 Activities)

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CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)

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ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)

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AR Tclin Androgen Receptor (11781 Activities)

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CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)

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MAOA Tclin Monoamine oxidase A (11911 Activities)

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DRD1 Tclin Dopamine D1 receptor (9720 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACHE Tclin Acetylcholinesterase (18204 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC6A2 Tclin Norepinephrine transporter (10102 Activities)

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SLC6A4 Tclin Serotonin transporter (12625 Activities)

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ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)

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HRH1 Tclin Histamine H1 receptor (7573 Activities)

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OPRM1 Tclin Mu opioid receptor (19785 Activities)

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DRD3 Tclin Dopamine D3 receptor (14368 Activities)

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OPRD1 Tclin Delta opioid receptor (15096 Activities)

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SLC6A3 Tclin Dopamine transporter (10535 Activities)

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KCNH2 Tclin HERG (29587 Activities)

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PDE3A Tclin Phosphodiesterase 3A (3309 Activities)

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ADRA2C Tclin Alpha-2c adrenergic receptor (4876 Activities)

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HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TBXA2R Tclin Thromboxane A2 receptor (5717 Activities)

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PDE4A Tclin Phosphodiesterase 4A (1943 Activities)

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ADORA3 Tchem Adenosine A3 receptor (15931 Activities)

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MIF Tchem Macrophage migration inhibitory factor (979 Activities)

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HRH3 Tclin Histamine H3 receptor (10389 Activities)

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KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)

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MC3R Tchem Melanocortin receptor 3 (5659 Activities)

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NR1I2 Tchem Pregnane X receptor (6667 Activities)

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Associated Targets(non-human)

Pde4d Phosphodiesterase 4D (4 Activities)

Discover Target: Pde4d

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Hdac6 Histone deacetylase 6 (222 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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SARS-CoV-2 (38078 Activities)

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Mechanisms of Action

Chemical and Physical Properties

• Sensitivity: Hygroscopic
• Melt Point(°C): 240 °C
• Molecular Weight: 374.400 g/mol
• XLogP3: 1.400
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 5
• Exact Mass: 374.057 Da
• Monoisotopic Mass: 374.057 Da
• Topological Polar Surface Area: 119.000 Ų
• Heavy Atom Count: 26
• Formal Charge: 0
• Complexity: 665.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Huan Xu, Kaixuan Ma, Ziting Ma, Tianyu Zhuang, Ling Lin.  (2025)  Iguratimod improves bleomycin-induced pulmonary inflammation and fibrosis by regulating macrophage polarization through inhibiting the TLR4/NF-κB pathway.  Frontiers in Immunology,      [PMID:40181990] [10.3389/fimmu.2025.1558903]

2. Du Li, Jindian Dong, Tong Xiong, Xingyu Zhou, Yanhui Li, Chuncheng Chen, Shijie Li, Zhuoyue Song, Nenggui Xu, Mingjing Yang, Xiaoxia Yan, Tao Liu, Shihui Liu.  (2024)  Transdermal delivery of iguratimod and colchicine ethosome by dissolving microneedle patch for the treatment of recurrent gout.  COLLOIDS AND SURFACES B-BIOINTERFACES,      [PMID:39003846] [10.1016/j.colsurfb.2024.114087]

3. Wenyan Yu, Xinyun Wu, Ming Li, Liya Mu, Yan Ma, Man Liu, Zhe Chen, Yage Luo, Jinjin Shi, Jitian Li.  (2025)  A Multifunctional Enzyme Cascade Catalytic Nanoplatform for Effective Synergistic Therapy of Rheumatoid Arthritis.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202423054]

4. Yuhuan Li, Longying Cong, Wei Zhang, Rongrong Zhang, Yu Gao, Songyun Zheng, Daowei Li, Zhuo Zhang, Lingyu Zhang, Modi Yang, Fei Chang.  (2025)  Macrophage Membrane-Coated Carbon Nanozymes for Targeted Drug Delivery and NIR-Responsive Synergistic Therapy in Rheumatoid Arthritis.  Advanced Healthcare Materials,      [PMID:41137690] [10.1002/adhm.202503316]