IOWH032 - 10mM in DMSO , Cystic fibrosis transmembrane conductance regulator inhibitor, CAS No.1191252-49-9, Cystic fibrosis transmembrane conductance regulator inhibitor

CAS: 1191252-49-9 Cat. No.: I420846 Fórmula: C22H15Br2N3O4 Peso molecular: 545.18
Disponível para encomenda
GRADE & PURITY 10mM in DMSO
Synonyms
LY-110,140 hydrochloride | Q27271180 | UNII-8Y3GDT6YWV | 3-(3,5-dibromo-4-hydroxyphenyl)-N-(4-phenoxybenzyl)-1,2,4-oxadiazole-5-carboxamide . | IOWH 032 | DSFNLJXHXBIKDS-UHFFFAOYSA-N | NCGC00386303-01 | AS-74457 | Propranolol hydrochloride intensol | SB17
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
★
Size
USA
Alemanha (EU)*
Price
Qty
1ml
I420846-1ml
1 Em stock
—
113,90US$
Enter a quantity for the sizes you want to add.
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Why this grade

10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Visão geral

IOWH032 is a synthetic CFTR inhibitor with IC50 of 1.01 μM in CHO-CFTR cell based assays. Phase 2.

Specifications

Sinónimos
LY-110,140 hydrochloride | Q27271180 | UNII-8Y3GDT6YWV | 3-(3,5-dibromo-4-hydroxyphenyl)-N-(4-phenoxybenzyl)-1,2,4-oxadiazole-5-carboxamide . | IOWH 032 | DSFNLJXHXBIKDS-UHFFFAOYSA-N | NCGC00386303-01 | AS-74457 | Propranolol hydrochloride intensol | SB17
Especificações e pureza
10mM in DMSO
Condições de armazenamento de armazenamento
Store at -80°C
Enviado em
Dry ice packs + Cold packs
Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.
Tipo de ação
INHIBITOR
Mecanismo de ação
Cystic fibrosis transmembrane conductance regulator inhibitor
Propriedades do produto
ALogP5.5
Nomes e identificadores
Pubchem Sid528764898
Sorrisos canónicosC1=CC=C(C=C1)OC2=CC=C(C=C2)CNC(=O)C3=NC(=NO3)C4=CC(=C(C(=C4)Br)O)Br
IUPAC Name3-(3,5-dibromo-4-hydroxyphenyl)-N-[(4-phenoxyphenyl)methyl]-1,2,4-oxadiazole-5-carboxamide
InChIKeyDSFNLJXHXBIKDS-UHFFFAOYSA-N
INCHI1S/C22H15Br2N3O4/c23-17-10-14(11-18(24)19(17)28)20-26-22(31-27-20)21(29)25-12-13-6-8-16(9-7-13)30-15-4-2-1-3-5-15/h1-11,28H,12H2,(H,25,29)
SMILES isoméricas C1=CC=C(C=C1)OC2=CC=C(C=C2)CNC(=O)C3=NC(=NO3)C4=CC(=C(C(=C4)Br)O)Br
Peso molecular 545.18
Reaxy-Rn 19545143
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=19545143&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassBenzenoids
ClasseBenzene and substituted derivatives
SubclassDiphenylethers
Intermediate Tree Nodes Not available
Direct ParentDiphenylethers
Alternative Parents Phenyloxadiazoles  Diarylethers  Phenoxy compounds  Phenol ethers  2-heteroaryl carboxamides  O-bromophenols  Bromobenzenes  Aryl bromides  Heteroaromatic compounds  Secondary carboxylic acid amides  Oxacyclic compounds  Azacyclic compounds  Organobromides  Organonitrogen compounds  Organopnictogen compounds  Organic oxides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteromonocyclic compounds
Substituents Diphenylether - Phenyl-1,2,4-oxadiazole - Diaryl ether - 2-heteroaryl carboxamide - Phenoxy compound - 2-halophenol - 2-bromophenol - Phenol ether - Bromobenzene - Halobenzene - Phenol - Aryl bromide - Aryl halide - 1,2,4-oxadiazole - Azole - Heteroaromatic compound - Oxadiazole - Secondary carboxylic acid amide - Carboxamide group - Organoheterocyclic compound - Azacycle - Oxacycle - Carboxylic acid derivative - Ether - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Organic nitrogen compound - Organohalogen compound - Organopnictogen compound - Organic oxygen compound - Organobromide - Organonitrogen compound - Aromatic heteromonocyclic compound
DescriçãoThis compound belongs to the class of organic compounds known as diphenylethers. These are aromatic compounds containing two benzene rings linked to each other through an ether group.
External Descriptors Not available
Estrutura 3D
Modelo de Estrutura Química Interativa





Alvos associados (não humanos)
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mecanismos de ação
Certificados(CoA,COO,BSE/TSE e Mapa de Análise)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propriedades químicas e físicas
Peso molecular545.200 g/mol
XLogP35.500
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass544.941 Da
Monoisotopic Mass542.943 Da
Topological Polar Surface Area97.500 Ų
Heavy Atom Count31
Formal Charge0
Complexity575.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Calculadoras de soluções
Revisões

Avaliações dos Clientes

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