JSH-23 - 10mM in DMSO , CAS No.749886-87-1

CAS: 749886-87-1 Cat. No.: J408370 Fórmula: C₁₆H₂₀N₂ Peso molecular: 240.34 Número CE: 685-995-5

GRADE & PURITY 10mM in DMSO

Synonyms

4-Methyl-N1-(3-phenylpropyl)benzene-1,2-diamine

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

JSH-23 JSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM in RAW 264.7 cell line.
In vitro

JSH-23 inhibits LPS-induced nuclear translocation of NF-κB p65 without affecting IκBα degradation. JSH-23 inhibits LPS-induced apoptotic chromatin condensation, while does not show significant cytotoxic effects on the RAW 264.7 cells at <100 μM. JSH-23 also decreases NO production and neuronal migration in LPS activated cultures primary cultures from developing mouse cerebellum. Moreover, JSH-23 augments cisplatin cytotoxicity in ovarian cancer cells with CI values ranging from 0.35 to 0.85.

In vivo

JSH-23 (3 mg/kg) significantly reverses the nerve conduction and nerve blood flow deficits by decreasing neuroinflammation and improving antioxidant defence in diabetic rats.
Cell Data

cell lines：

Concentrations：~300 μM

Incubation Time：24 hours

Powder Purity:≥99%

Specifications

Sinónimos

4-Methyl-N1-(3-phenylpropyl)benzene-1,2-diamine

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

JSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM in RAW 264.7 cell line.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

INHIBITOR

Nomes e identificadores

• SMILES isoméricas: CC1=CC(=C(C=C1)NCCCC2=CC=CC=C2)N
• WGK Alemanha: 3
• Peso molecular: 240.34
• Reaxy-Rn: 24398255
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24398255&ln=

Propriedades químicas e físicas

• Ponto de fusão (°C): 103 °C