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L18I is a PROTAC targeting Btk that can reduce inflammation in autoimmune diseases such as lupus erythematosus induced by BM12 splenocytes. L18I is composed of PROTAC target protein ligand IBT6A (red part), PROTAC Linker Propargyl-PEG3-alcohol (balck part) and E3 ubiquitin ligase ligand Lenalidomide-Br (blue part), of which the active control of the target protein ligand is IBT6A -CO-ethyne , and the conjugate of E3 ubiquitin ligase ligand + Linker is Lenalidomide-C3-PEG3-N3.
| CAS | 2451070-32-7 |
|---|---|
| Condições de armazenamento de armazenamento | Store at -20°C |
| Enviado em | Ice chest + Ice pads |
| Product Description | L18I is a PROTAC targeting Btk that can reduce inflammation in autoimmune diseases such as lupus erythematosus induced by BM12 splenocytes. L18I is composed of PROTAC target protein ligand IBT6A (red part), PROTAC Linker Propargyl-PEG3-alcohol (balck part) and E3 ubiquitin ligase ligand Lenalidomide-Br (blue part), of which the active control of the target protein ligand is IBT6A -CO-ethyne , and the conjugate of E3 ubiquitin ligase ligand + Linker is Lenalidomide-C3-PEG3-N3. |