Mecamylamine hydrochloride - 10mM in DMSO , Neuronal acetylcholine receptor; alpha3/beta4 negative allosteric modulator, CAS No.826-39-1, Neuronal acetylcholine receptor; alpha3/beta4 negative allosteric modulator

CAS: 826-39-1 Cat. No.: M426136 Fórmula: C₁₁H₂₁N · HCl Peso molecular: 203.75 Número CE: 212-555-8

GRADE & PURITY 10mM in DMSO

Synonyms

Inversine | Mevasin | 2-[1,2,4]Triazol-1-ylmethyl-benzoicacid | Mecamine hydrochloride | MECAMYLAMINE HYDROCHLORIDE [MART.] | Mecamylamine, HCl | NCGC00094171-01 | CHEBI:6707 | N,2,3,3-tetramethyl-2-norcamphanamine hydrochloride | 2-(Methylamino)isocampha

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Mecamylamine Hydrochloride is a noncompetitive and nonselective antagonist of AChRs. The compound preferentially blocks nicotinic receptors at autonomic ganglia and is able to cross the blood brain barrier. Once across the blood brain barrier Mecamylamine Hydrochloride can selectively antagonize neuronal AChRs. Mecamylamine Hydrochloride is an inhibitor of AChR α 3, AChR α 4, AChR α 7 and AChRβ2.
A noncompetitive nicotinic AChR inhibitor.

Specifications

Sinónimos

Inversine | Mevasin | 2-[1,2,4]Triazol-1-ylmethyl-benzoicacid | Mecamine hydrochloride | MECAMYLAMINE HYDROCHLORIDE [MART.] | Mecamylamine, HCl | NCGC00094171-01 | CHEBI:6707 | N,2,3,3-tetramethyl-2-norcamphanamine hydrochloride | 2-(Methylamino)isocampha

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

Noncompetitive nicotinic acetylcholine receptor antagonist; preferentially blocks nicotinic receptors at autonomic ganglia; crosses blood-brain barrier.Non-competitive, non-selective antagonist of nicotinic actelycholine receptors (nAChRs). Blood-brain ba

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

NEGATIVE ALLOSTERIC MODULATOR

Mecanismo de ação

Neuronal acetylcholine receptor; alpha3/beta4 negative allosteric modulator

Nomes e identificadores

• Pubchem Sid: 508815069
• Sorrisos canónicos: CC1(C2CCC(C2)C1(C)NC)C.Cl
• IUPAC Name: N,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine;hydrochloride
• InChIKey: PKVZBNCYEICAQP-UHFFFAOYSA-N
• INCHI: 1S/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H
• SMILES isoméricas: CC1(C2CCC(C2)C1(C)NC)C.Cl
• WGK Alemanha: 3
• RTECS: RB6900000
• CAS alternativo: 60-40-2
• Peso molecular: 203.75
• Reaxy-Rn: 7097642
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7097642&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Classe Prenol lipids
      • Subclass Monoterpenoids

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Classe: Prenol lipids
• Subclass: Monoterpenoids
• Intermediate Tree Nodes: Not available
• Direct Parent: Bicyclic monoterpenoids
• Alternative Parents: Dialkylamines Organopnictogen compounds Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Aliphatic homopolycyclic compounds
• Substituents: Bicyclic monoterpenoid - Secondary amine - Secondary aliphatic amine - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Hydrochloride - Organonitrogen compound - Amine - Aliphatic homopolycyclic compound
• Descrição: This compound belongs to the class of organic compounds known as bicyclic monoterpenoids. These are monoterpenoids containing exactly 2 rings, which are fused to each other.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Alvos associados (humanos)

U2OS (164939 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLI Tchem DNA polymerase iota (116820 Activities)

Discover Target: POLI

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

Discover Target: SLCO1B1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

Discover Target: SLCO1B3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HEK-293T (167025 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Alvos associados (não humanos)

Plasmodium falciparum (966862 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de ação

Propriedades químicas e físicas

• Peso molecular: 203.750 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 203.144 Da
• Monoisotopic Mass: 203.144 Da
• Topological Polar Surface Area: 12.000 Ų
• Heavy Atom Count: 13
• Formal Charge: 0
• Complexity: 197.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 3
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3