MHY1485 - 10mM in DMSO , CAS No.326914-06-1

CAS: 326914-06-1 Cat. No.: M408199 Fórmula: C₁₇H₂₁N₇O₄ Peso molecular: 387.39

GRADE & PURITY 10mM in DMSO

Synonyms

4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

MHY1485 MHY1485 is a potent, and cell-permeable mTOR activator, and also potently inhibits autophagy .
In vitro

MHY1485 suppresses the basal autophagic flux. MHY1485 causes the accumulation of LC3II and enlargement of the autophagosomes in a dose- and time- dependent manner. MHY1485 increases phospho-mTOR levels and phosphorylation of downstream S6K1 and rpS6 proteins without affecting total mTOR content, total S6K1 and rpS6 levels. Short-term treatment of ovaries with MHY1485 followed by allo-transplantation promoted secondary follicle growth. Treatment with MHY1485 and subsequent grafting allowed the derivation of mature oocytes and healthy offspring.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥97%

Specifications

Sinónimos

4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

MHY1485 is a potent, and cell-permeable mTOR activator, and also potently inhibits autophagy.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

INHIBITOR

Nomes e identificadores

SMILES isoméricas

C1COCCN1C2=NC(=NC(=N2)NC3=CC=C(C=C3)[N+](=O)[O-])N4CCOCC4

Peso molecular

387.39

Reaxy-Rn

9952068

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9952068&ln=

Propriedades químicas e físicas

• Ponto de fusão (°C): 259°C