MRT68921 HCl - ≥98% , CAS No.1190379-70-4(freebase)

CAS: 1190379-70-4(freebase) Cat. No.: M413884 Fórmula: C₂₅H₃₄N₆O·xHCl Peso molecular: 434.6（freebase）

GRADE & PURITY ≥98%

Synonyms

N-​[3-​[[5-​cyclopropyl-​2-​[(1,​2,​3,​4-​tetrahydro-​2-​methyl-​6-​isoquinolinyl)​amino]​-​4-​pyrimidinyl]​amino]​propyl]​-Cyclobutanecarboxamide hydrochloride

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

Information

MRT68921 HCl MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.

Targets

ULK2 (Cell-free assay); ULK1 (Cell-free assay) 1.1 nM; 2.9 nM

In vitro

MRT68921 specifically disrupts autophagosome maturation and thus blocks autophagic flux through ULK1 inhibition.

Cell Research(from reference)

Cell lines：MEFs and 293T cells 

Concentrations：1 μM 

Incubation Time：1 h 

Specifications

Sinónimos

N-​[3-​[[5-​cyclopropyl-​2-​[(1,​2,​3,​4-​tetrahydro-​2-​methyl-​6-​isoquinolinyl)​amino]​-​4-​pyrimidinyl]​amino]​propyl]​-Cyclobutanecarboxamide hydrochloride

Especificações e pureza

≥98%

Mecanismos bioquímicos e fisiológicos

MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.Mrt68921 hydrochloride has cytotoxicity and kills cancer cells by acting on oxidative stress signals. It is an effective tumor therapeutic drug. M

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Pureza

≥98%

Propriedades do produto

ALogP

4.644

hba_count

3

Contagem HBD

3

Ligação rotativa

9

Nomes e identificadores

Sorrisos canónicos

CN1CCC2=C(C1)C=CC(=C2)NC3=NC=C(C4CC4)C(=N3)NCCCNC(=O)C5CCC5

CAS alternativo

2080306-21-2

Peso molecular

434.6（freebase）

Reaxy-Rn

19608518

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=19608518&ln=

Propriedades químicas e físicas

• Solubilidade: Solubility (25°C) In vitro DMSO: 10 mg/mL warmed with 50ºC Water: bath Water: Insoluble; Ethanol: Insoluble
• DMSO (mg/mL) Solubilidade máxima: 10
• DMSO (mM) Solubilidade máxima: 23.010723
• Água (mg/mL) Solubilidade máxima: ＜1

Perguntas frequentes

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1190379-70-4(freebase), the molecular formula is C25H34N6O·xHCl, and the molecular weight is 434.6（freebase） g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.