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Ver folha de especificações →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic Polymers |
| Classe | Polypeptides |
| Subclass | Not available |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Polypeptides |
| Alternative Parents | Peptides Tyrosine and derivatives Arginine and derivatives Phenylalanine and derivatives Glutamic acid and derivatives Glutamine and derivatives Aspartic acid and derivatives Isoleucine and derivatives Leucine and derivatives Valine and derivatives N-acyl-L-alpha-amino acids Serine and derivatives Alpha amino acid amides Amphetamines and derivatives Tricarboxylic acids and derivatives Aralkylamines 1-hydroxy-2-unsubstituted benzenoids N-acyl amines Amino acids Secondary carboxylic acid amides Primary carboxylic acid amides Guanidines Carboximidamides Carboxylic acids Carbonyl compounds Hydrocarbon derivatives Organic oxides Imines Monoalkylamines Primary alcohols |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Polypeptide - Alpha peptide - Tyrosine or derivatives - Arginine or derivatives - Phenylalanine or derivatives - Glutamic acid or derivatives - Glutamine or derivatives - Aspartic acid or derivatives - Leucine or derivatives - Isoleucine or derivatives - N-acyl-alpha-amino acid - N-acyl-alpha amino acid or derivatives - N-acyl-l-alpha-amino acid - Valine or derivatives - Serine or derivatives - Alpha-amino acid amide - Alpha-amino acid or derivatives - N-substituted-alpha-amino acid - Amphetamine or derivatives - Tricarboxylic acid or derivatives - Phenol - Aralkylamine - 1-hydroxy-2-unsubstituted benzenoid - Monocyclic benzene moiety - Fatty acyl - Fatty amide - N-acyl-amine - Benzenoid - Secondary carboxylic acid amide - Primary carboxylic acid amide - Carboxamide group - Amino acid - Guanidine - Amino acid or derivatives - Carboximidamide - Carboxylic acid derivative - Carboxylic acid - Organooxygen compound - Organic oxygen compound - Organic nitrogen compound - Primary alcohol - Carbonyl group - Primary amine - Alcohol - Hydrocarbon derivative - Amine - Organic oxide - Organonitrogen compound - Imine - Primary aliphatic amine - Aromatic homomonocyclic compound |
| Descrição | This compound belongs to the class of organic compounds known as polypeptides. These are peptides containing ten or more amino acid residues. |
| External Descriptors | Not available |
| Alternate Names | UNII-D45TI2TWMA | Nerinetide | Tat NR2B9c | AKOS040740169 | L-Valine, L-tyrosylglycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L- glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-lysyl-L-leucyl-L-seryl-L-seryl-L-isoleucyl-L-alpha-glutamyl-L-seryl-L-alpha-a |
|---|---|
| Reference |
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No tested application protocols are provided for this SKU in the Product Data.
General preparation (literature guidance; not item-specific):
For detailed, validated protocols (e.g., neuronal cultures, biophysical binding assays, pulldowns), consult peer-reviewed literature on nerinetide-class peptides and adapt to your laboratory’s SOPs. Ensure your sequence, salt form, and purity match those in the selected reference before reproducing conditions.
Context (literature; not an item-specific claim): Nerinetide-class peptides are reported as cell-penetrating, positively charged sequences designed to mimic a PDZ-binding motif and thereby competitively modulate scaffolding proteins such as PSD-95 in neuronal signaling pathways.
Important note: The above summarizes commonly reported research uses and biological context from the literature. This product is offered strictly for laboratory research; no claims are made regarding suitability for diagnostic or therapeutic applications. Verify sequence, purity, and salt form on the CoA to ensure alignment with your experimental design.
This product is a peptide reagent and not a buffering agent. Therefore, conventional buffer system design (e.g., phosphate, Tris, HEPES) is outside the primary scope for this item.
Practical notes (general):
For buffer recipes, pH ranges, and ionic strength optimization, refer to standard buffer preparation references. Choose buffers that do not interfere with your downstream assay (e.g., avoid high concentrations of multivalent anions when working with polybasic peptides).
For peptide reagents such as nerinetide, the main environmental considerations are solvent choice, buffer components, and waste minimization. The guidance below is general/literature-based and not item-specific.
Greener solvent choices:
Comparison (general):
Operational best practices:
Energy and storage:
Disposal:
No pharmaceutical or clinical use is claimed or supported for this catalog item; it is supplied exclusively for laboratory research use.
Formulation considerations (general, literature-based for peptide reagents used in preclinical research settings; not item-specific):
Regulatory note: No pharmacopeial monograph, excipient designation, or GMP status is specified for this item. Researchers requiring regulated-grade material should consult the CoA and contact technical support regarding available documentation or alternate grades.
Item-specific physico-chemical values are not provided for this listing.
Practical notes (general): Wetting the powder with a small volume of solvent, brief sonication, and gradual dilution can assist dissolution. Filter sterilization (0.22 μm) may be used if compatible with intended use.
What to expect and verify (recommendations):
Implications for use:
This catalog entry is supplied for research use as a peptide/ligand. No manufacturer application notes are provided for this SKU. The following are general, literature-based uses of nerinetide-class peptides; verify suitability for your experiment.
Practical tips (general):
No chemical reaction conditions specific to this item are provided. The following are general, literature-based conditions relevant to peptide derivatization and assay preparation:
Cautions:
These conditions are provided as general guidance only; optimize for your specific sequence and application.
Authoritative safety information for this item is not specified; always consult the SDS prior to use.
Storage per Product Data: Store at room temperature (as supplied). See Storage & Reconstitution for additional guidance after opening/reconstitution.
Nerinetide is a peptide entry; solvent selection follows general principles for basic, cell-penetrating peptides (literature guidance; not item-specific specifications).
Comparison (literature expectations):
Tip: Determine concentration by UV at 214–220 nm (peptide bond) or 280 nm if aromatic residues are present (literature). Use sequence-based extinction coefficients when available.
Reconstitution (general, literature-based guidance for peptides; not item-specific):
Post-reconstitution storage (general):
Note: Exact stability, solubility, and concentration limits are sequence- and salt-form dependent. For definitive guidance, consult the item’s CoA/Spec Sheet.
Brief overview: Nerinetide is listed as a research peptide/ligand entry in our small-molecule and compound library category. Item-specific structural identifiers are largely not provided in the current listing.
Structural features (general literature context, not item-specific specifications):
Important note: Specific sequence, exact counterion state, terminal modifications, salt form, and peptide length for this catalog item are not specified here; consult the CoA/Spec Sheet for definitive identity and analytical confirmation (HPLC, MS, peptide mapping).
While nerinetide itself is typically used as a biological probe rather than a synthetic building block, peptide chemistry around this class affords several synthetic utilities (general/literature guidance):
Note: Specific sequence, protective group history, counterion, and terminal modifications for this catalog item are not specified; if synthetic derivatization is planned, confirm these details on the CoA or request custom synthesis support to ensure compatibility with your chemistry.
Item-specific target information is not provided in the Product Data for this SKU.
If your application requires validated target engagement data (e.g., KD, IC50, or domain specificity), please consult the primary literature associated with nerinetide-class peptides and verify the exact sequence and purity on the CoA for this catalog item before use.
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