NH-3 - 10mM in DMSO , CAS No.447415-26-1

CAS: 447415-26-1 Cat. No.: N655269 Molecular Weight: 473.52 PubChem CID: 10027822

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC 50 of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment

In Vivo

NH3 (46.2-27,700 nmol/kg/day; 7 days) decreases heart rate modestly starting at 46.2 nmol/kg/day, but the effect was lost at >2920 nmol/kg/day. NH3 has no effect on the cholesterol-lowering action of 46.2 nmol/kg/day T3, but it inhibits the tachycardic and TSH suppressant effects up to the 924 nmol/kg/day dose. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50: 55 nM (THR)

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC 50 of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment [1

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ANTAGONIST

Names and Identifiers

• Isomeric SMILES: CC1=CC(=CC(=C1CC2=CC(=C(C(=C2)C(C)C)O)C#CC3=CC=C(C=C3)[N+](=O)[O-])C)OCC(=O)O
• PubChem CID: 10027822
• Molecular Weight: 473.52