Moligand™, 10 mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 12 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Nitrocefin is a highly activated, chromogenic cephalosporin derivative. Nitrocefin is a chromogenic β-lactamase substrate. Nitrocefin undergoes a distinctive color change from yellow to red as the amide bond in the β-lactam ring is hydrolyzed by β-lactamase. Nitrocefin is used in competitive inhibition studies in developmental work on β-lactamase-resistant antibiotics .
| Isomeric SMILES | C1C(=C(N2[C@H](S1)[C@@H](C2=O)NC(=O)CC3=CC=CS3)C(=O)O)/C=C/C4=C(C=C(C=C4)[N+](=O)[O-])[N+](=O)[O-] |
|---|---|
| PubChem CID | 6436140 |
| Molecular Weight | 516.5 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Melt Point(°C) | >99℃ |
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| 1. Ru Wang, Kun Mi, Aihua Lu, Chengyang Zhang, Lei Sun, Yuxiang Chen, Yuanhu Pan, Yanfei Tao, Lingli Huang. (2025) Postβ-Lactamase-Inhibiting Effect of Sulbactam in Combination with Ceftriaxone on Extended-Spectrum-β-Lactamase-Producing Escherichia coli. Antibiotics-Basel, 14 (9): (915). [PMID:41009894] [10.3390/antibiotics14090915] |
| 2. Shu-Fei Yuan, Xin-Jing Yue, Wei-Feng Hu, Ye Wang, Yue-Zhong Li. (2023) Genome-wide analysis of lipolytic enzymes and characterization of a high-tolerant carboxylesterase from Sorangium cellulosum. Frontiers in Microbiology, [PMID:38111649] [10.3389/fmicb.2023.1304233] |
| 3. Aparna Vasudevan, Dinesh Kumar Kesavan, Liang Wu, Zhaoliang Su, Shengjun Wang, Mohan Kumar Ramasamy, Waheeta Hopper, Huaxi Xu. (2022) In Silico and In Vitro Screening of Natural Compounds as Broad-Spectrum β-Lactamase Inhibitors against Acinetobacter baumannii New Delhi Metallo-β-lactamase-1 (NDM-1). Biomed Research International, [PMID:35372567] [10.1155/2022/4230788] |
| 4. Haonan Sun, Yunjian Yu, Yufei Zhang, Jie Li, Yijie Cheng, Siyuan Huang, Wenbo Wang, Xinge Zhang. (2021) Glycosylated Nanotherapeutics with β-Lactamase Reversible Competitive Inhibitory Activity Reinvigorates Antibiotics against Gram-Negative Bacteria. BIOMACROMOLECULES, [PMID:34164980] [10.1021/acs.biomac.1c00231] |
| 5. Maohu Chen, Bo Qiu, Zhanlin Zhang, Shuang Xie, Yuan Liu, Tian Xia, Xiaohong Li. (2021) Light-triggerable and pH/lipase-responsive release of antibiotics and β-lactamase inhibitors from host-guest self-assembled micelles to combat biofilms and resistant bacteria. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2021.130330] |
| 6. Dongmei Zhao, Hongru Li, Chengcheng Yue, Kaili Sun, Yuanyuan Dai, Hui Zhang, Yanyan Liu, Yufeng Gao, Jiabin Li. (2021) Captopril potentiated meropenem activity against MBL-producing carbapenem-resistant Klebsiella pneumoniae: in vitro and in vivo study. JOURNAL OF INORGANIC BIOCHEMISTRY, [PMID:33647540] [10.1016/j.jinorgbio.2021.111381] |
| 7. Minrui Liu, Hongyuhang Ni, Ling Yang, Gang Chen, Xiaojun Yan, Xiaoyun Leng, Pu Liu, Xiangkai Li. (2019) Pretreatment of swine manure containing β-lactam antibiotics with whole-cell biocatalyst to improve biogas production. Journal of Cleaner Production, [PMID:] [10.1016/j.jclepro.2019.118070] |
| 8. Lei Xu, Sangyu Hu, Yuzhu Pei, Yutong Zhou, Xiuli Zhang, Linlin Ding, Minhe Cui, Yonglin Zhou, Xuming Deng, Zihao Teng, Jianfeng Wang. (2025) Docosahexaenoic Acid-Driven Metabolic Reprogramming as an Attractive Anti-Infection Strategy to Potentiate β-Lactam Antibiotic Efficacy. Research, [PMID:41383405] [10.34133/research.0650] |
| 9. Cheng Wenhui, Zhang Yuejuan, Chen Cheng, Gao Lei, Lv Yuwei, Yu Dian, Chen Bin, Wan Yi. (2024) Identification of α-mangostin as a potent inhibitor of β-lactamase OXA-48. MEDICINAL CHEMISTRY RESEARCH, [PMID:] [10.1007/s00044-023-03185-w] |
| 10. Wenyan Jiang, Shan Zhang, Chen Xu, Haojie Sun, Ziye Xing, Xiao Liang, Hongming He, Quanshun Li. (2025) Sustainable biodegradation of antibiotic residues in aqueous environment using OXA-48 β-lactamase encapsulated in spherical mesoporous covalent organic frameworks. JOURNAL OF HAZARDOUS MATERIALS, [PMID:40499418] [10.1016/j.jhazmat.2025.138856] |
| 11. Hao Tang, Xiaomeng Zhao, Mengsi Sun, Jie Qi, Zhihao Huang, Yihang Zhu, Yingmin Zeng, Yong Xia, Zhi Luo, Xingyu Jiang. (2025) Chemically tailored anionic antibiotic adjuvants targeting divalent cations to overcome carbapenem resistance in gram-negative bacteria. Science Advances, 11 (43): [PMID:41124267] [10.1126/sciadv.adz0574] |
| 12. Jing Wu, Ziqian Xiao, Yuhui Du, Minglan Luo, Jiacheng Zhang, Pei Guo, Zhipeng Chen, Binyuan Yang, Tingjian Chen. (2025) Generation of Stable 2’-F/OMe-RNA Aptasensors for Bacillus cereus 5/B/6 Metallo-β-Lactamase. ACS Synthetic Biology, [PMID:41236492] [10.1021/acssynbio.5c00547] |
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