🌎 Enviar para: United States
Menu
Carrinho
Pesquisar
Envio no mesmo dia para todos os itens em stock.
Pesquisa Avançada
Encomenda rápida SDS / CoA Estrutura Bulk & Personalizado
Menu
Conta
Configurações
྾
340,000+ produtos de pesquisa · Triple ISO certified · COA & SDS Disponível para todos os produtos · Envio no mesmo dia em itens em estoque

Nrf2 peptide, Inhibitor of kelch like ECH-associated protein 1, CAS No.rp174671, Inhibitor of kelch like ECH-associated protein 1

CAS: rp174671 Cat. No.: rp174671 PubChem CID: 73355065
COA
Nrf2 peptide, Inhibitor of kelch like ECH-associated protein 1, CAS No.rp174671, Inhibitor of kelch like ECH-associated protein 1
Disponível para encomenda
GRAU & PUREZA Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
★
Tamanho
USA
Alemanha (EU)*
Preço
Qtd
500μg
rp174671-500μg
Fabricado sob encomenda nos EUA · 2–4 semanas ·
—
2399,90US$
1mg
rp174671-1mg
Fabricado sob encomenda nos EUA · 2–4 semanas ·
—
3999,90US$
Enter a quantity for the sizes you want to add.
A granel / Personalizado
♡ Lista de desejos ⇅ Adicionar à Comparação ⎙ Imprimir página
SDS
Safety data
COA
Certificate
DS
Ficha técnica
SP
Folha de especificações
Especificações Armazenamento e envio Documentação Dados avançados Taxonomic Classification Alvos associados (humanos) Mecanismos de ação Certificados（CoA,COO,BSE/TSE e Mapa de Análise) Informação genética Calculadoras de soluções Revisões Perguntas frequentes Application Protocols Biological Roles Buffer Applications Green Alternatives Pharmaceutical Uses Physical Properties Quality and Grades Reaction and Applications Reaction Conditions Safety and Handling Solvent Selection Storage and Reconstitution Structure and Identity Synthetic Utility Target Specificity
🧪
Por que este grau

Moligand™ Moligand™ para fluxos de trabalho cromatográficos e analíticos sensíveis que exigem interferência mínima da linha de base.

🌡

Armazenamento e envio

Room temperature Envio . Consulte o COA específico do lote para obter as especificações exatas.

📋

Documentos de qualidade

SDS, COA, ficha técnica e folha de especificações disponíveis para download. COA específico do lote acessível por meio de pesquisa por número de lote.

📚

Comprovação documental

Citado em 0 publicações revisadas por pares nas áreas de cromatografia, síntese orgânica e reações de acoplamento cruzado.

Especificações

Product Name
Nrf2 peptide, Inhibitor of kelch like ECH-associated protein 1, CAS No.rp174671
Grau
Moligand™
Especificações e pureza
Moligand™
Tipo de ação
INHIBITOR
Mecanismo de ação
Inhibitor of kelch like ECH-associated protein 1
CAS
rp174671
Tipo de molécula
Proteína
Product Line
Produtos biológicos
Armazenamento e envio
Condições de armazenamento de armazenamento
Room temperature

Documentação

📋 Ficha de dados de segurança (FDS)

Documento abrangente sobre perigos, manuseamento, armazenamento e conformidade regulamentar.

<<<<<<< HEAD Baixar SDS → ======= Baixar SDS → >>>>>>> release248-p3

✅ Certificado de análise (COA)

Dados de qualidade específicos do lote. Introduza o número de lote para obter o COA exato.

Consultar COA →

📊 Ficha técnica

Resumo de referência rápida das especificações e aplicações do produto.

Ver ficha técnica →

🔬 Folha de especificações

Atributos de qualidade completos e critérios de aceitação para este grau.

Ver folha de especificações →

Dados avançados

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic Polymers
ClassePolypeptides
SubclassNot available
Intermediate Tree Nodes Not available
Direct ParentPolypeptides
Alternative Parents Peptides  Phenylalanine and derivatives  Pentacarboxylic acids and derivatives  Glutamic acid and derivatives  Glutamine and derivatives  Aspartic acid and derivatives  Leucine and derivatives  N-acyl-L-alpha-amino acids  Alpha amino acid amides  Alanine and derivatives  Amphetamines and derivatives  N-acyl amines  Secondary alcohols  Secondary carboxylic acid amides  Amino acids  Primary carboxylic acid amides  Carboxylic acids  Monoalkylamines  Hydrocarbon derivatives  Carbonyl compounds  Organic oxides  
Molecular FrameworkAromatic homomonocyclic compounds
Substituents Polypeptide - Alpha peptide - Phenylalanine or derivatives - Pentacarboxylic acid or derivatives - Glutamine or derivatives - Glutamic acid or derivatives - Leucine or derivatives - Aspartic acid or derivatives - N-acyl-l-alpha-amino acid - N-acyl-alpha amino acid or derivatives - N-acyl-alpha-amino acid - Alpha-amino acid amide - Alanine or derivatives - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - Amphetamine or derivatives - N-acyl-amine - Fatty amide - Benzenoid - Fatty acyl - Monocyclic benzene moiety - Amino acid or derivatives - Amino acid - Carboxamide group - Secondary carboxylic acid amide - Secondary alcohol - Primary carboxylic acid amide - Carboxylic acid - Carboxylic acid derivative - Organic oxide - Organic oxygen compound - Carbonyl group - Hydrocarbon derivative - Organic nitrogen compound - Primary aliphatic amine - Amine - Alcohol - Primary amine - Organonitrogen compound - Organooxygen compound - Aromatic homomonocyclic compound
DescriçãoThis compound belongs to the class of organic compounds known as polypeptides. These are peptides containing ten or more amino acid residues.
External Descriptors Not available
Alvos associados (humanos)
KEAP1 Tclin Kelch-like ECH-associated protein 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KEAP1 Tclin Kelch-like ECH-associated protein 1 (1736 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mecanismos de ação
Certificados（CoA,COO,BSE/TSE e Mapa de Análise)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Informação genética
Reference
  • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
  • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
  • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
  • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
  • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
  • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
  • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
  • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
  • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
  • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more
Calculadoras de soluções
Revisões

Avaliações dos Clientes

Application Protocols

Only information from the Product Data may be listed here.

  • Tested applications (e.g., FP, SPR, ITC, pull-down), recommended dilutions, positive controls, or example workflows: Not specified for this item; refer to product page or CoA/Spec Sheet.

General note

  • For guidance on common assay formats applicable to Nrf2-related peptides, see the Reaction Conditions tab (literature/general suggestions). These are not validated for this specific item.
Biological Roles

Context (literature/general)

  • Nrf2 (NFE2L2) is a cap’n’collar transcription factor that, upon stabilization and nuclear translocation, binds antioxidant response elements (ARE) to upregulate cytoprotective and redox-homeostasis genes.
  • Under basal conditions, Keap1 recruits Nrf2 for Cullin3-dependent ubiquitination and proteasomal turnover. Two Nrf2 motifs, DLG and ETGE, anchor to the Keap1 Kelch domain with differing affinities (“hinge and latch” model).

Role of Nrf2-derived peptides in research (literature/general)

  • Motif-mimetic peptides emulate the Nrf2 binding elements to probe or competitively modulate the Keap1–Nrf2 interaction in vitro.
  • Such peptides are valuable as reference ligands to benchmark small-molecule PPI inhibitors, to map binding energetics, or to validate assay formats.
  • Sequence variations, point mutations, or chemical modifications (e.g., stapling, noncanonical residues) are often used to tune affinity, proteolytic stability, or biophysical readouts for in vitro studies.

Item-specific

  • This listing does not provide a sequence, modifications, or demonstrated biological activity. No claims are made regarding potency, selectivity, or cellular effects for this item. For research use only.

Implications

  • When used in biochemical assays, Nrf2-related peptides help delineate binding determinants and support mechanistic studies of oxidative stress response regulation without invoking cellular/clinical outcomes.
Buffer Applications

Item-specific buffer recommendations are not provided for this product.

General guidance for peptide buffers (literature/general)

  • Solubilization
    • Start with water or 10–20 mM HEPES, PBS, or Tris at pH 7.2–7.5. Adjust pH gradually if solubility is limited; acidic motif peptides may prefer neutral-to-basic pH.
    • If needed, pre-dissolve in a minimal volume of DMSO or DMF, then dilute into buffer while mixing; keep final organic ≤1–2% for most protein assays.
  • Working concentrations
    • Binding/biophysical assays commonly use 0.05–50 µM peptide, depending on Kd and detection modality (FP, SPR, ITC) — optimize empirically.
  • Additives
    • 0.005–0.05% nonionic surfactant (e.g., Tween-20) can reduce nonspecific adsorption/aggregation; 0.1–1 mM TCEP or DTT may be used only if disulfide-containing peptides/proteins require reducing conditions.
  • Ionic strength
    • 100–200 mM NaCl is typical for minimizing nonspecific electrostatics in PPI assays; adjust to maintain protein stability.
  • Filtration and sterility
    • Filter 0.22 µm for cell-free assays to remove particulates and bioburden. For cell-based work (if undertaken), ensure sterility and endotoxin controls; however, no cellular application is specified for this item.

Note: Tailor buffer composition to the protein partner’s stability and the detection technique’s requirements.

Green Alternatives

Not typically applicable. This product is a peptide research ligand, not a solvent or bulk reagent where greener substituents are directly interchangeable.

General considerations (literature/general)

  • Minimize DMSO use: Keep co-solvent fractions as low as feasible in assays; consider aqueous buffers first.
  • Scale responsibly: Prepare only the amount needed for immediate use to reduce waste of peptide and solvents.
  • Aqueous work: Where compatible, prioritize water-based buffers over organic media to reduce environmental footprint.
  • Waste management: Segregate peptide-containing solutions and dispose per institutional guidelines to avoid unnecessary incineration volumes.

If your workflow heavily relies on organic co-solvents or denaturants, consider greener buffer systems or solvent-recovery practices; however, direct “green alternative” substitutions for this peptide are not applicable.

Pharmaceutical Uses

Not applicable for this catalog item. This Nrf2 peptide is offered strictly for research use only (as stated). No pharmacopeial monograph, dosage form, or excipient role is specified for this item.

General context (literature/general)

  • Nrf2-derived peptides are typically employed as in vitro research ligands or assay controls rather than as formulation components.
  • For any exploratory preformulation studies (e.g., stability screens of peptides), requirements include rigorous identity/purity documentation, sterility/bioburden controls, and stability-indicating methods — none of which are specified here for pharmaceutical deployment.

Conclusion

  • Do not use in humans or in clinical settings. For research and laboratory investigations only.
Physical Properties

Item-specific values

  • Appearance: Not specified for this item; refer to CoA/Spec Sheet.
  • Molecular Weight: Not specified for this item; refer to CoA/Spec Sheet.
  • Molecular Formula: Not specified for this item; refer to CoA/Spec Sheet.
  • Other specifications (mp/bp, density, pI): Not specified for this item; refer to CoA/Spec Sheet.

General properties of research peptides (literature/general)

  • Physical state: Typically provided as a lyophilized powder or film; hygroscopic tendencies vary with sequence and counter-ions.
  • Solubility behavior: Strongly sequence-dependent. Acidic Nrf2-motif peptides (e.g., ETGE-containing) often dissolve readily in water at neutral-to-basic pH; initial wetting with dilute aqueous base (e.g., 0.1 M NaOH, dropwise) or with small volumes of DMSO can assist dissolution. For hydrophobic sequences, co-solvents like DMSO or DMF are commonly used before dilution into buffers.
  • Isoelectric point (pI): Determined by side chains; acidic motif peptides typically have low pI (<6), while basic/Arg–Lys-rich peptides have higher pI (>9). Specific pI is sequence-dependent.
  • Stability: In solid form, peptides are generally stable when kept dry and protected from light and moisture. In solution, they may be susceptible to hydrolysis, oxidation (Met, Cys, Trp), and microbial growth; antioxidant or inert-atmosphere handling can be beneficial for oxidation-prone sequences.
  • UV characteristics: Peptides absorb at 190–220 nm (peptide bond). Aromatic residues (Trp, Tyr, Phe) contribute at ~280/274/257 nm; actual ε depends on composition.

All numerical values for this specific item are not provided here; consult the CoA/spec sheet for definitive specifications.

Quality and Grades

  • Item-specific

    • Grade/Purity designation: Moligand™ (as provided). Specific assay purity, sequence verification method, residual solvent/water content, and counter-ion identity are not specified for this item; refer to CoA/Spec Sheet.

  • About Moligand™ (general context)

    • Moligand™ denotes inclusion in a ligand-focused research collection intended for discovery and screening workflows. While exact acceptance criteria vary by product, collections typically emphasize verified identity and purity suitable for biochemical assays and profiling (literature/general description).

  • Typical quality controls for research peptides (literature/general)

    • Identity confirmation by LC–MS/HRMS; sequence validation by tandem MS and/or NMR when applicable.
    • Purity assessment via analytical RP-HPLC with UV detection; reporting of area % purity relative to total detected species.
    • Counter-ion and salt-form reporting (e.g., TFA, acetate) and water content (Karl Fischer) are often provided in the CoA.

  • Practical implications

    • For quantitative binding or biophysical assays (e.g., SPR, ITC, FP), purity and accurate mass are critical; request and review the CoA before protocol finalization.
    • If ultra-low UV background or trace-metal specifications are required, confirm with the CoA; such parameters are Not specified for this item.

  • Traceables and documentation

    • Batch-specific CoA, analytical chromatograms, and MS data are recommended for audit trails in screening campaigns; obtain these prior to large-scale studies.
Reaction and Applications

This product is a peptide research tool rather than a synthetic reagent; its relevance lies in biochemical and biophysical applications.

  • Item-specific: Manufacturer application text not provided; sequence and modifications are not specified.

  • Typical research applications for Nrf2-related peptides (literature/general)

    • Protein–protein interaction studies: Model the Nrf2 motifs (e.g., ETGE or DLG) that bind the Keap1 Kelch domain; used as ligands or competitors in binding assays.
    • Assay development: Fluorescence polarization (FP) displacement, surface plasmon resonance (SPR), microscale thermophoresis (MST), isothermal titration calorimetry (ITC) to quantify binding affinities of test molecules that target the Keap1–Nrf2 interface.
    • Structural biology: Serve as co-crystallization ligands or cryo-EM binders to define binding pockets and validate pharmacophores.
    • Biochemical controls: Positive controls in HTS campaigns aimed at discovering Keap1–Nrf2 PPI modulators.

  • Practical tips (general)

    • Prepare fresh solutions; aliquot to avoid repeated freeze–thaw (if frozen) and adsorption to plastic. Low-bind tubes can reduce losses for short peptides.
    • Verify concentration by absorbance (if aromatic residues present) or by quantitative amino acid analysis; gravimetric error can be significant for hygroscopic materials.
    • Include appropriate counter-screening to exclude nonspecific aggregators (e.g., include nonionic detergent at low levels, DLS checks).

Note: Specific binding constants or assay-ready labeling (e.g., FAM, biotin) are not specified for this item; consult the CoA/spec sheet.

Reaction Conditions

As a peptide ligand, this product is used in assays rather than chemical reactions. The following are general literature-based assay conditions for Nrf2/Keap1 peptide studies; adapt to your platform.

  • Fluorescence polarization (FP) displacement (literature/general)

    • Buffer: 10–50 mM HEPES or PBS, 100–150 mM NaCl, pH 7.2–7.5; 0.005–0.01% Tween-20 optional.
    • Protein: Keap1 Kelch domain at 5–50 nM; fluorescent tracer peptide at 0.5–5 nM near its Kd.
    • Competitor peptide: Serial dilutions (e.g., 0.1 nM–100 µM). Incubate 15–60 min at room temperature before reading.

  • Surface plasmon resonance (SPR) (literature/general)

    • Immobilization: Keap1 or biotinylated peptide captured on CM5/SA chips.
    • Running buffer: HEPES-buffered saline with surfactant (HBS-EP). Flow 25–50 µL/min.
    • Temperature: 20–25°C. Multi-cycle kinetics with association 60–180 s, dissociation 300–600 s.

  • Isothermal titration calorimetry (ITC) (literature/general)

    • Buffer matching between syringe and cell; 50–200 µM peptide titrated into 5–20 µM protein at 25°C.

  • MST/biolayer interferometry (general)

    • Similar pH/ionic strength as above; maintain low DMSO (<1–2%).

Item-specific

  • No assay-validated concentrations, labels, or binding constants are provided for this item. Optimize empirically and consult the CoA for any available guidance.
Safety and Handling

Authoritative safety information resides in the SDS; follow institutional EHS guidelines.

  • GHS classification, signal word, pictograms, H-statements (item-specific): Not specified for this item; refer to SDS.

  • General laboratory precautions for peptides (literature/general)

    • Avoid inhalation of dust/aerosols; handle powders in a fume hood or ventilated enclosure.
    • Prevent skin and eye contact; wear appropriate PPE: lab coat, safety glasses, and disposable nitrile gloves.
    • Use clean tools (spatulas, micro-scoops) to minimize contamination; keep container tightly closed to limit moisture uptake.
    • If dissolution requires organic co-solvents (e.g., DMSO, DMF), observe those solvents’ specific hazards and exposure limits.

  • First-aid overview (general)

    • Inhalation: Move to fresh air; seek medical advice if symptoms persist.
    • Skin/eye contact: Rinse with water for at least 15 minutes; remove contaminated clothing; seek medical attention for irritation.
    • Ingestion: Rinse mouth with water; do not induce vomiting; seek medical attention.

  • Incompatibilities and special risks (general)

    • Avoid strong oxidizers if the peptide contains oxidation-sensitive residues (Cys, Met, Trp); store away from bases/acids that could catalyze hydrolysis in solution.
    • Microbial contamination risk in aqueous solutions; prepare under aseptic conditions if sterility is required, and consider filtration through 0.22 µm membranes.

  • Waste disposal

    • Dispose of peptide solutions and contaminated materials according to local regulations and institutional policies for organic/biological laboratory waste.
Solvent Selection

This section guides dissolution and buffer selection for peptide handling.

  • Item-specific: No solubility data provided for this peptide; sequence and modifications are not specified. Consult the CoA/Spec Sheet for any provided guidance.

  • General strategy for peptide dissolution (literature/general)

    • Start small: Add a minimal volume of solvent, then dilute into the final buffer.
    • Aqueous first if feasible: Try water, PBS, or HEPES at pH away from the peptide’s pI (unknown here). For acidic Nrf2-motif peptides, neutral-to-basic pH often improves solubility.
    • Assistants: If insoluble, use 10–50% DMSO or a small volume of neat DMSO/DMF to pre-dissolve, then titrate with buffer while mixing. Ultrasound can help.
    • Salts and pH: Adjust pH incrementally with dilute NaOH or HCl; avoid strong base/acid that can cause degradation.
    • Filtration: 0.22 µm filtration removes particulates and bioburden prior to sensitive assays.

  • Buffer compatibility (general)

    • For binding assays (e.g., Keap1–peptide), low-detergent, low-carrier protein conditions are typical to avoid nonspecific interactions; include 0.005–0.05% Tween-20 only if needed.
    • Avoid high concentrations of chaotropes or denaturants unless specifically required.

  • Comparison to alternatives

    • Water/PBS: Biocompatible, minimal UV background; limited for hydrophobic sequences.
    • HEPES/Tris: Good buffering at physiological pH; minimal metal chelation compared to phosphate in some systems.
    • DMSO: Powerful co-solvent; maintain ≤1–2% in final biophysical assays to protect protein integrity (general guidance).

Note: Final solvent choice should be validated empirically for the intended assay.

Storage and Reconstitution

  • Item-specific storage

    • Storage Conditions: Room temperature (as provided in Product Data).
    • Shipped In: Not specified for this item; refer to CoA/Spec Sheet.
    • Appearance: Not specified for this item; refer to CoA/Spec Sheet.

  • General best practices for peptides (literature/general)

    • Solid form: Keep tightly closed in a dry environment at room temperature or as specified. Protect from moisture and light. Desiccant and inert atmosphere can help preserve oxidation-sensitive sequences.
    • Reconstitution: Use sterile water or assay buffer; if solubility is limited, pre-wet with a small volume of DMSO, then dilute with buffer. Adjust pH gradually if needed. Record the exact solvent composition for reproducibility.
    • Working solutions: Prepare aliquots to avoid repeated freeze–thaw. For long-term retention of activity in solution, storage at ≤−20°C is commonly practiced; avoid prolonged storage at ambient temperature once reconstituted.
    • Container choice: Low-bind polypropylene tubes can minimize adsorption losses, particularly for short or hydrophobic peptides.
    • Stability checks: Verify concentration and integrity periodically (HPLC/LC–MS) for critical assays.

  • Research Use Note

    • For research use only. Not for human or clinical use.

For any batch-specific stability or reconstitution recommendations unique to this item, consult the CoA/Spec Sheet.

Structure and Identity

Brief description: Nrf2 peptide is a peptide tool compound related to the Nrf2 (NFE2L2) pathway. Sequence, composition, and length are not provided in this listing.

  • Item-specific (from Product Data)

    • SKU: rp174671
    • Product Name: Nrf2 peptide
    • CAS: rp174671 (catalog/reference identifier as provided)
    • CID: 73355065 (as provided)
    • InChIKey: 209807 (as provided)
    • SMILES: Not specified for this item; refer to CoA/Spec Sheet.
    • Molecular Formula: Not specified for this item; refer to CoA/Spec Sheet.
    • Molecular Weight: Not specified for this item; refer to CoA/Spec Sheet.

  • Structural features (general peptide chemistry; literature/general)

    • Composed of amino acid residues linked via amide (peptide) bonds, featuring a repeating –NH–C(=O)– backbone with side chains (R-groups) that define charge and hydropathy.
    • Typical Nrf2-derived peptides used in research model the ETGE and/or DLG motifs that engage Keap1’s Kelch domain; these motifs are enriched in acidic residues that foster electrostatic and H-bond interactions (literature).

  • 2D description in words (general)

    • A linear oligomer of α-amino acids with terminal amino and carboxyl groups (unless capped). Side-chain functionality (acidic, basic, polar, hydrophobic) determines net charge at experimental pH, solubility, and binding to protein partners.

Notes: Exact sequence, modifications (e.g., acetylation/amidation, labels), and stereochemistry (usually L-amino acids) are not specified for this item; consult the CoA or spec sheet if needed.

Synthetic Utility

This product is a peptide ligand and is not typically used as a general synthetic reagent.

General notes (literature/general)

  • Reference standard: Can serve as a reference ligand in assay-guided discovery of small molecules targeting the Keap1–Nrf2 interface, enabling calibration curves and benchmarking.
  • Conjugation chemistry: If supplied with free N-terminus, Lys, or Cys (not specified here), standard bioconjugation strategies (NHS ester acylation, maleimide–thiol coupling, click chemistry after azide/alkyne installation) could be applied to prepare labeled derivatives for assay readouts. Any such functionality for this item is not specified.
  • SPPS relevance: Provides a sequence template for solid-phase peptide synthesis optimization, alanine scanning, or motif substitution studies (ETGE/DLG analogs) used to map binding determinants (general research practice).

Item-specific statement

  • No synthetic-grade specifications, protective-group patterns, or labeling handles are disclosed for this item. Treat it as a finished research peptide rather than a building block.
Target Specificity

Only information from the Product Data may be listed here.

  • Item-specific
    • Target, epitope/motif, species reactivity, and any binding selectivity data: Not specified for this item; refer to product page or CoA/Spec Sheet if available.

No further specificity claims are made.

Perguntas frequentes

What is Moligand??
Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.
How should this product be stored?
Store at room temperature.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is rp174671. InChIKey LUWNQRCIIOOCLS-ITDBXDHNSA-N.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

Precisa de ajuda para escolher o grau?

O nosso guia de seleção de graus abrange pureza, estado do estabilizador e adequação à aplicação para todas as variantes do nosso catálogo.

Ver o guia de graus Moligand™ →
Embalagem a granel e personalizada Precisa de quantidades maiores ou especificações personalizadas? Contacte a nossa equipa para obter um orçamento à medida.

View related series

kelch like ECH-associated protein 1 Inhibitor (1)
Usamos cookies para garantir o funcionamento adequado do site e, quando permitido, para melhorar a sua experiência. Você pode gerenciar suas preferências a qualquer momento nas Configurações. Saiba mais em nossa Política de Cookies.

Deseja que lhe enviemos uma mensagem quando tivermos descontos disponíveis?

Lembrar-me mais tarde

Obrigado! Por favor, verifique a sua caixa de entrada de e-mail para confirmar.

Ops! As notificações estão desativadas.

Privacy Policy Terms of Use Cookie Policy Terms and Conditions of Sale Sales Policy
Products are supplied to verified businesses, institutions, and qualified professionals for research and development use only. Not for use in humans, animals, diagnosis, or therapy.
Copyright © 2023–present Aladdin Scientific Corporation. All rights reserved.