p63 Mouse mAb - Anticorpo primário, specific to Tumor protein 63, Mouse IgG2b

Cat. No.: Ab119899

GRADE & PURITY Carrier Free, Validated, ExactAb™, High Performance, See COA

Application

WB

Host species

Rato

Reactive species

Humano, Porco

Isotype

Mouse IgG2b

Clone Number

D2

Conjugation

Unconjugated

Visão geral

Mouse anti Human p63 Antibody, Monoclonal (D2), could be used for WB and so on.
Application:
WB: 0.01-2 µg/mL
Protein Function
Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge.

Specifications

Product Name

p63 Mouse mAb - Anticorpo primário, specific to Tumor protein 63, Mouse IgG2b

Sinónimos

AIS antibody | Amplified in squamous cell carcinoma antibody | B(p51A) antibody | B(p51B) antibody | Chronic ulcerative stomatitis protein antibody | CUSP antibody | DN p63 alpha 1 antibody | DNp63 antibody | EEC3 antibody | id:ibd3516 antibody | Keratino

Especificações e pureza

Carrier Free, ExactAb™, Validated, High Performance, See COA

Espécie hospedeira

Rato

Especificidade

Tumor protein 63

Imunogénio

Recombinant TP63 expressed in E.coli (AA 540~680)

Controlo positivo

WB: A431 cell lysate.

Conjugação

Unconjugated

Grau

Carrier Free, ExactAb™, High Performance, Validated

Isótipo

Mouse IgG2b

Tipo de corrente de luz

kappa

SDS-PAGE

150 kDa

Método de purificação

Protein A + Protein G affinity purified

Concentração

See COA

Armazenamento e envio

Forma

Liquid

Condições de armazenamento de armazenamento

Store at -20°C,Avoid repeated freezing and thawing

Enviado em

Ice chest + Ice pads

Estabilidade e armazenamento

Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Imagens

Western Blot: p63 Mouse mAb (Ab119899)

p63 Mouse mAb (Ab119899) - Western Blot
All lanes: p63 Mouse mAb (Ab119899) at 1/2000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Mouse IgG H&L (HRP) (Ab138040) at 1/20000 dilution

Predicted band size: 77 kDa
Observed band size: 72 kDa
Exposure time: 55.6 s

Aplicação

• Aplicação: Dilution info
• WB:

  0.01-2 µg/mL ;

Alvos associados (humanos)

TP63 Tbio Tumor protein 63 (0 Activities)

Discover Target: TP63

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Perguntas frequentes

What does ExactAb? mean?

ExactAb? indicates the product has been validated for use in rigorous antibody validation workflows. Validation may include positive/negative control samples, signal-to-noise testing, and protocol-specific QC. Lot-specific test data is published on the Certificate of Analysis where available.

What does Carrier Free mean?

Carrier Free indicates that the material has been processed and tested for specialty industrial processing. Specifications focus on the impurities that affect performance in that application — for example, metal content for electronics, particle size for batteries, refractive index for optics, or moisture content for moisture-sensitive processes.

How should this product be stored?

Store at ?20 °C. Avoid repeated freeze–thaw cycles. Aliquot into single-use volumes before freezing.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

Which species reactivity has this antibody been validated against?

Validated reactivity is listed on the PDP and on each lot's datasheet. We validate against the most commonly tested species for the target (p63 Mouse mAb); cross-reactivity in untested species may exist but is not guaranteed. Contact technical support for specific species inquiries.