10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
PF-06256142 is a potent, selective, CNS-penetrant and orally active agonist of the D1 receptor , with an EC 50 and K i of 33 nM and 12 nM, respectively. PF-06256142 has the potential for the research of schizophrenia and Parkinson's disease
In Vitro
PF-06256142 exhibits IC 50 values of <5 μM as an antagonist at the following 4 targets: M 1 (4.9 μM); CB1 (2.1 μM); H 1 (4.6 μM); Nav 1.5 (1.1 μM). PF-06256142 has an IC 50 of approximately 12 μM for hERG. PF-06256142 shows a K i of 4.8 nM for D5 exquisitely selective than D2 (K i >10 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
PF-06256142 exhibits high oral bioavailability (rat 85%) following oral administration (rat 5 mg/kg) . PF-06256142 exhibits terminal elimination half-life (rat 2.3 h) following intravenous administration (rat 5.0 mg/kg) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Rat Dosage: 5.0 mg/kg for i.v.; 5 mg/kg for oral (Pharmacokinetic Analysis) Administration: Intravenous injection and oral administration Result: Oral bioavailability (85%), T 1/2 (2.3 h).
IC50& Target:Human D 1 Receptor 33 nM (EC 50 )
| Isomeric SMILES | CC1=C(C=CC(=C1)OC2=NC=CC3=C2C=CO3)C4=C(N=CC5=NC=CN54)C |
|---|---|
| PubChem CID | 75201901 |
| Molecular Weight | 388.44 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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