PF-06305591 - 10mM in DMSO , CAS No.1449473-97-5

CAS: 1449473-97-5 Cat. No.: P655943 Fórmula: C₁₅H₂₂N₄O Peso molecular: 274.36 PubChem CID: 71666749

GRAU & PUREZA 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

PF-06305591 is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with an IC 50 of 15 nM. An excellent preclinical in vitro ADME and safety profile

In Vitro

PF-06305591 (compound 9) has a highly attractive profile with respect to NaV selectivity, hERG activity, passive permeability and in vitro metabolic stability. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PF-06305591 (compound 9) has good rat bioavailability. PF-06305591 offers the possibility of investigating higher IC 50 multiples of Nav1.8 blockade in the clinic, and therefore a more thorough evaluation of the role of NaV1.8 in the treatment of pain . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Na v 1.8 15 nM (IC 50 )

Especificações

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

PF-06305591 is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with an IC 50 of 15 nM. An excellent preclinical in vitro ADME and safety profile.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

INHIBITOR

Nomes e identificadores

SMILES isoméricas

C[C@H]([C@@H](C1=NC2=C(N1)C=C(C=C2)C(C)(C)C)N)C(=O)N

CAS alternativo

1449473-97-5

PubChem CID

71666749

Peso molecular

274.36

Alvos associados (humanos)

SCN10A Tclin Sodium channel protein type 10 subunit alpha (1 Activities)

Discover Target: SCN10A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Perguntas frequentes

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1449473-97-5, the molecular formula is C15H22N4O, and the molecular weight is 274.36 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.