PFK15 - Moligand™, 10mM in DMSO , Inhibitor of 6-phosphofructo-2-kinase/fructose-2;6-biphosphatase 3, CAS No.4382-63-2, Inhibitor of 6-phosphofructo-2-kinase/fructose-2;6-biphosphatase 3

CAS: 4382-63-2 Cat. No.: P407887 Fórmula: C₁₇H₁₂N₂O Peso molecular: 260.29 Número CE: 809-326-5 PubChem CID: 25142799

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

PFK-015 | 2-​Propen-​1-​one, 1-​(4-​pyridinyl)​-​3-​(2-​quinolinyl)​-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

PFK15 PFK15 (PFK-015) is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM.
In vitro

PFK15 produces potent growth inhibition in a series of cancer cells. In Jurkat T-cell leukemia cells and H522 lung adenocarcinoma cells, PFK15 also reduces F26BP, glucose uptake, and intracellular ATP level.

In vivo

In vivo, PFK15 has adequate pharmacokinetic properties. PFK15 (25 mg/kg i.p.) suppresses the growth, metastatic spread, and glucose metabolism of LLC tumors in syngeneic mice. In three human xenograft models of cancer in athymic mice, PFK15 also yields antitumor effects that are comparable to approved chemotherapeutic agents.
Cell Data

cell lines：

Concentrations：~30 μM

Incubation Time：48 hours

Powder Purity:≥99%

Specifications

Sinónimos

PFK-015 | 2-​Propen-​1-​one, 1-​(4-​pyridinyl)​-​3-​(2-​quinolinyl)​-

Especificações e pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos e fisiológicos

PFK15 (PFK-015) is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Tipo de ação

INHIBITOR

Mecanismo de ação

Inhibitor of 6-phosphofructo-2-kinase/fructose-2;6-biphosphatase 3

Nomes e identificadores

• SMILES isoméricas: C1=CC=C2C(=C1)C=CC(=N2)/C=C/C(=O)C3=CC=NC=C3
• WGK Alemanha: 3
• CAS alternativo: 4382-63-2
• PubChem CID: 25142799
• Termos de entrada MeSH: 1-(4-pyridinyl)-3-(2-quinolinyl)-2-propen-1-one;PFK15
• Peso molecular: 260.29

Alvos associados (humanos)

PFKFB3 Tchem 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (1 Activities)

Discover Target: PFKFB3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)