Pitavastatin - Moligand™, 10 mM in DMSO , CAS No.147511-69-1

CAS: 147511-69-1 Cat. No.: P1499322 Fórmula: C₂₅H₂₄FNO₄ Peso molecular: 421.46 Número CE: 643-092-3 PubChem CID: 5282452

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC 50 of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects .

Specifications

Especificações e pureza

Moligand™, 10 mM in DMSO

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Nomes e identificadores

• SMILES isoméricas: C1CC1C2=NC3=CC=CC=C3C(=C2/C=C/[C@H](C[C@H](CC(=O)O)O)O)C4=CC=C(C=C4)F
• PubChem CID: 5282452
• Peso molecular: 421.46

Propriedades químicas e físicas

• Ponto de inflamação (°C): 372.3±31.5 ℃
• Ponto de ebulição (°C): 692.0±55.0℃ at 760 mmHg

Referências

1. Anning Yang, Hongwen Zhang, Huiping Zhang, Nan Li, Cong Chen, Xiaoling Yang, Jue Tian, Jianmin Sun, Guizhong Li, Yue Sun, Bin Liu, Yideng Jiang.  (2025)  Pitavastatin and resveratrol bio-nanocomplexes against hyperhomocysteinemia-induced atherosclerosis via blocking ferroptosis-related lipid deposition.  JOURNAL OF CONTROLLED RELEASE,      [PMID:40043912] [10.1016/j.jconrel.2025.113598]

2. Yizhou Wu, Hongyan Zhou, Hao Liu, Jiayao Hu, Yue Sun, Wei Yan, Chunyi Tong, Ying Kong, Bin Liu.  (2025)  Pitavastatin-loaded procyanidins self-assembled nanoparticles alleviate advanced atherosclerosis via modulating macrophage efferocytosis and cholesterol efflux.  Acta Pharmaceutica Sinica B,      [PMID:40654339] [10.1016/j.apsb.2024.08.006]