Pomalidomide-PEG₄-Alkyne

Cat. No.: P487818

Synonyms

Protein degrader building block for PROTAC research, Crosslinker–E3 Ligase ligand conjugate, Template for synthesis of targeted protein degrader, N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-4,7,10,13-tetraoxahexadec-15-ynamide

Storage

Store at 2-8°C

Shipped In

Wet ice

Visão geral

Description

Protein degrader builiding block Pomalidomide-PEG4-Alkyne enables the synthesis of molecules fortargeted protein degradation andPROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blockswith a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Specifications

Sinónimos

Protein degrader building block for PROTAC research, Crosslinker–E3 Ligase ligand conjugate, Template for synthesis of targeted protein degrader, N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-4,7,10,13-tetraoxahexadec-15-ynamide

Informações legais

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Condições de armazenamento de armazenamento

Store at 2-8°C

Enviado em

Wet ice

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.