S 3304 - 10mM in DMSO , CAS No.203640-27-1

CAS: 203640-27-1 Cat. No.: S656084 Fórmula: C₂₄H₂₀N₂O₄S₂ Peso molecular: 464.6 PubChem CID: 10718956

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

S 3304 is a novel matrix metalloproteinases ( MMP ) inhibitor specific for MMP-2 and MMP-9 .

In Vitro

S 3304 is a novel D-tryptophan derivative and a potent, orally active, noncytotoxic Matrix metalloproteinases inhibitor (MMPI). Biochemical studies show that S 3304 most potently inhibits the activities of MMP-2 and MMP-9 but does not inhibit MMP-1, MMP-3, or MMP-7 and may, therefore, lack the musculoskeletal side effects seen with nonspecific inhibitors. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In vivo pharmacologic studies have shown that the oral administration of S 3304, at a dose range of 20 to 200 mg/kg, inhibits angiogenesis, artificially induced in mice by the dorsal air-sac method. Similar oral doses of S 3304 result in potent inhibition of metastatic lung colonization of Lewis murine lung carcinoma injected via tail vein and liver metastasis of C-1H human colon cancer implanted into the spleen . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:MMP-9

Specifications

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

S 3304 is a novel matrix metalloproteinases ( MMP ) inhibitor specific for MMP-2 and MMP-9 .

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Nomes e identificadores

• SMILES isoméricas: CC1=CC=C(C=C1)C#CC2=CC=C(S2)S(=O)(=O)N[C@H](CC3=CNC4=CC=CC=C43)C(=O)O
• CAS alternativo: 203640-27-1
• PubChem CID: 10718956
• Termos de entrada MeSH: S 3304;S-3304;S3304 cpd
• Peso molecular: 464.6

Alvos associados (humanos)

MMP9 Tchem Matrix metalloproteinase-9 (2 Activities)

Discover Target: MMP9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP2 Tchem 72 kDa type IV collagenase (2 Activities)

Discover Target: MMP2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Perguntas frequentes

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 203640-27-1, the molecular formula is C24H20N2O4S2, and the molecular weight is 464.6 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.