SEN177 - 10mM in DMSO , CAS No.2117405-13-5

CAS: 2117405-13-5 Cat. No.: S655452 Fórmula: C₁₈H₁₉FN₆ Peso molecular: 338.38 Número CE: 821-054-9 PubChem CID: 91618245

GRAU & PUREZA 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

SEN177 is a potent glutaminyl cyclase (QPCT) inhibitor with an IC 50 of 0.013μM for glutaminyl-peptide cyclotransferase-like (QPCTL). SEN177 has a K i of 20 nM for human glutaminyl cyclase (hQC). SEN177 greatly reduces the early stages of mutant HTT oligomerisation and reduces the percentage of neurons with Q80 aggregates. SEN177 has the potential for Huntington’s disease research.

Especificações

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

SEN177 is a potent glutaminyl cyclase (QPCT) inhibitor with an IC 50 of 0.013μM for glutaminyl-peptide cyclotransferase-like (QPCTL). SEN177 has a K i of 20 nM for human glutaminyl cyclase (hQC). SEN177 greatly reduces the early stages of mutant HTT oligo

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Nomes e identificadores

SMILES isoméricas

CN1C=NN=C1C2CCN(CC2)C3=C(C=CC=N3)C4=CN=C(C=C4)F

CAS alternativo

2117405-13-5

PubChem CID

91618245

Peso molecular

338.38

Alvos associados (humanos)

QPCT Tchem Glutaminyl-peptide cyclotransferase (1 Activities)

Discover Target: QPCT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)