CONJUNTO 2 - Moligand™, ≥98%(HPLC) , Channel blocker of TRPV2, CAS No.2313525-20-9, Channel blocker of TRPV2

CAS: 2313525-20-9 Cat. No.: S287626 Fórmula: C₁₇H₂₁F₃N₄O₂S Peso molecular: 402.44 PubChem CID: 155541857

GRAU & PUREZA Moligand™, ≥98%(HPLC)

Synonyms

TRPV2 antagonist SET2 | N-(Furan-2-ylmethyl)-3-((4-(methyl(propyl)amino)-6-(trifluoromethyl)pyrimidin-2-yl)thio)propanamide | AKOS040755628 | HY-132222 | DTXSID101336558 | GTPL12547 | 2313525-20-9 | N-(Furan-2-ylmethyl)-3-(4-(methyl(propyl)amino)-6-(trifl

Storage

Armazenar a -20°C

Shipped In

Arca de gelo + almofadas de gelo

Especificações

Sinónimos

TRPV2 antagonist SET2 | N-(Furan-2-ylmethyl)-3-((4-(methyl(propyl)amino)-6-(trifluoromethyl)pyrimidin-2-yl)thio)propanamide | AKOS040755628 | HY-132222 | DTXSID101336558 | GTPL12547 | 2313525-20-9 | N-(Furan-2-ylmethyl)-3-(4-(methyl(propyl)amino)-6-(trifl

Especificações e pureza

Moligand™, ≥98%(HPLC)

Mecanismos bioquímicos e fisiológicos

Antagonista do TRPV2 (recetor transiente potencial vanilóide tipo 2) (IC50= 0,46 μM). Seletivo para TRPV2 em relação a TRPV1, TRPV3 e TRPV4 expressos em células HEK293. Inibe a migração de células de cancro da próstata induzida pelo ácido liofosfatídico (

Condições de armazenamento de armazenamento

Armazenar a -20°C

Enviado em

Arca de gelo + almofadas de gelo

Grau

Moligand™

Tipo de ação

CHANNEL BLOCKER

Mecanismo de ação

Channel blocker of TRPV2

Pureza

≥98%(HPLC)

Nomes e identificadores

Pubchem Sid

488203091

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/488203091

Sorrisos canónicos

CCCN(C)C1=NC(=NC(=C1)C(F)(F)F)SCCC(=O)NCC2=CC=CO2

IUPAC Name

N-(furan-2-ylmethyl)-3-[4-[methyl(propyl)amino]-6-(trifluoromethyl)pyrimidin-2-yl]sulfanylpropanamide

InChIKey

LZHSWRWIMQRTOP-UHFFFAOYSA-N

INCHI

1S/C17H21F3N4O2S/c1-3-7-24(2)14-10-13(17(18,19)20)22-16(23-14)27-9-6-15(25)21-11-12-5-4-8-26-12/h4-5,8,10H,3,6-7,9,11H2,1-2H3,(H,21,25)

SMILES isoméricas

CCCN(C)C1=NC(=NC(=C1)C(F)(F)F)SCCC(=O)NCC2=CC=CO2

PubChem CID

155541857

Peso molecular

402.44

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organosulfur compounds
    • Classe Thioethers
      • Subclass Aryl thioethers

• Kingdom: Organic compounds
• Superclass: Organosulfur compounds
• Classe: Thioethers
• Subclass: Aryl thioethers
• Intermediate Tree Nodes: Not available
• Direct Parent: Aryl thioethers
• Alternative Parents: Dialkylarylamines Aminopyrimidines and derivatives Alkylarylthioethers Imidolactams Heteroaromatic compounds Furans Amino acids and derivatives Sulfenyl compounds Propargyl-type 1,3-dipolar organic compounds Oxacyclic compounds Carboxylic acid amides Carboximidamides Azacyclic compounds Amidines Organopnictogen compounds Organooxygen compounds Organofluorides Organic oxides Hydrocarbon derivatives Alkyl fluorides
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Aryl thioether - Dialkylarylamine - Tertiary aliphatic/aromatic amine - Alkylarylthioether - Aminopyrimidine - Imidolactam - Pyrimidine - Heteroaromatic compound - Furan - Tertiary amine - Carboxamide group - Amino acid or derivatives - Oxacycle - Azacycle - Organoheterocyclic compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Sulfenyl compound - Carboximidamide - Carboxylic acid derivative - Amidine - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Amine - Alkyl halide - Alkyl fluoride - Aromatic heteromonocyclic compound
• Descrição: This compound belongs to the class of organic compounds known as aryl thioethers. These are organosulfur compounds containing a thioether group that is substituted by an aryl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Alvos associados (humanos)

TRPV2 Tchem Transient receptor potential cation channel subfamily V member 2 (0 Activities)

Discover Target: TRPV2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPV4 Tchem Transient receptor potential cation channel subfamily V member 4 (774 Activities)

Discover Target: TRPV4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TRPV3 Tchem Transient receptor potential cation channel subfamily V member 3 (542 Activities)

Discover Target: TRPV3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Alvos associados (não humanos)

Trpv2 Transient receptor potential cation channel subfamily V member 2 (148 Activities)

Discover Target: Trpv2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Trpv1 Transient receptor potential cation channel subfamily V member 1 (45 Activities)

Discover Target: Trpv1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de ação

Propriedades químicas e físicas

• Solubilidade: Solvent:DMSO, Max Conc. mg/mL: 40.24, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 20.12, Max Conc. mM: 50