SL-327 - Moligand™, ≥98%, mixture of isomers , Inhibitor of mitogen-activated protein kinase kinase 2, CAS No.305350-87-2, Inhibitor of mitogen-activated protein kinase kinase 2

CAS: 305350-87-2 Cat. No.: S125929 Fórmula: C₁₆H₁₂F₃N₃S Peso molecular: 335.35 Número CE: 878-717-0 PubChem CID: 9549284

GRAU & PUREZA Moligand™, ≥98%, mixture of isomers

Synonyms

CCG-206867 | STL555675 | Benzeneacetonitrile, alpha-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)- | HY-15437 | SCHEMBL570318 | BCP05310 | FT-0600361 | Q27084156 | AC-33170 | NCGC00092290-01 | (Z)-3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluor

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Visão geral

SL327 inhibits MEK1 and MEK2, with IC50 values of 180 nM and 220 nM, respectively.

Especificações

Sinónimos

CCG-206867 | STL555675 | Benzeneacetonitrile, alpha-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)- | HY-15437 | SCHEMBL570318 | BCP05310 | FT-0600361 | Q27084156 | AC-33170 | NCGC00092290-01 | (Z)-3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluor

Especificações e pureza

Moligand™, ≥98%, mixture of isomers

Mecanismos bioquímicos e fisiológicos

SL-327 is a cell-permeable vinylogous cyanamide that acts as a selective inhibitor of MEK-1 and MEK-2 (IC50 = 0.18 and 0.22 μM respectively). SL-327 has been shown to block hippocampal LTP via inhibition of the MAPK/ERK cascade, which prevents CREB and

Condições de armazenamento de armazenamento

Store at -20°C,Argon charged

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Tipo de ação

INHIBITOR

Mecanismo de ação

Inhibitor of mitogen-activated protein kinase kinase 2

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureza

≥98%

Nomes e identificadores

Pubchem Sid

504764808

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504764808

Sorrisos canónicos

C1=CC=C(C(=C1)C(=C(N)SC2=CC=C(C=C2)N)C#N)C(F)(F)F

IUPAC Name

(Z)-3-amino-3-(4-aminophenyl)sulfanyl-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile

InChIKey

JLOXTZFYJNCPIS-FYWRMAATSA-N

INCHI

1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+

SMILES isoméricas

C1=CC=C(C(=C1)/C(=C(\N)/SC2=CC=C(C=C2)N)/C#N)C(F)(F)F

WGK Alemanha

3

PubChem CID

9549284

Peso molecular

335.35

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Benzene and substituted derivatives
      • Subclass Trifluoromethylbenzenes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Benzene and substituted derivatives
• Subclass: Trifluoromethylbenzenes
• Intermediate Tree Nodes: Not available
• Direct Parent: Trifluoromethylbenzenes
• Alternative Parents: Aryl thioethers Aniline and substituted anilines Ketene acetals Sulfenyl compounds Nitriles Primary amines Organofluorides Hydrocarbon derivatives Alkyl fluorides
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Trifluoromethylbenzene - Aniline or substituted anilines - Aryl thioether - Ketene acetal or derivatives - Sulfenyl compound - Nitrile - Carbonitrile - Hydrocarbon derivative - Organic nitrogen compound - Primary amine - Organosulfur compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Alkyl fluoride - Amine - Alkyl halide - Cyanide - Aromatic homomonocyclic compound
• Descrição: This compound belongs to the class of organic compounds known as trifluoromethylbenzenes. These are organofluorine compounds that contain a benzene ring substituted with one or more trifluoromethyl groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Alvos associados (humanos)

MAP2K2 Tclin Dual specificity mitogen-activated protein kinase kinase 2 (1 Activities)

Discover Target: MAP2K2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propriedades químicas e físicas

• Solubilidade: DMSO 4 mg/mL Water <1 mg/mL Ethanol 7 mg/mL
• Sensibilidade: Light Sensitive,Air Sensitive,Moisture Sensitive,Heat Sensitive
• Ponto de fusão (°C): 128 °C
• Peso molecular: 335.300 g/mol
• XLogP3: 3.700
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 3
• Exact Mass: 335.07 Da
• Monoisotopic Mass: 335.07 Da
• Topological Polar Surface Area: 101.000 Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 487.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1