GRADE & PURITYMoligand™?Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.10mM in DMSO
Moligand™,10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Visão geral
Sovilnesib (AMG 650) is a potent, orally active kinesin-like protein KIF18A inhibitor with an IC 50 value of 0.071 μM. Sovilnesib can be used for the research of cancer
In Vitro
Sovilnesib (AMG 650; 0-10 pM; 96 and 144 h; cancer cell lines) has anti-proliferative activity and inhibits tumor cell growth in a dose-dependent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Cancer cell lines Concentration: 0-10 pM Incubation Time: 96 and 144 hours Result: Inhibited tumor cell growth in a dose-dependent manner.
In Vivo
Sovilnesib (AMG 650; 10-100 mg/kg; p.o. daily, for 45 d; female nude mice without thymus with OVCAR-3 xenografts) inhibits tumor growth, Lasting tumor regression and cure occurred in 50% of the animals, Sovilnesib has no apparent toxicity . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female nude mice without thymus with OVCAR-3 xenografts Dosage: 10, 30, and 100 mg/kg Administration: Oral administration; daily, for 45 days Result: Had antitumor efficacy in a dose-dependent manner.
IC50& Target:KIF18A
Specifications
Especificações e pureza
Moligand™,10mM in DMSO
Mecanismos bioquímicos e fisiológicos
Sovilnesib (AMG 650) is a potent, orally active kinesin-like protein KIF18A inhibitor with an IC 50 value of 0.071 μM. Sovilnesib can be used for the research of cancer.
Condições de armazenamento de armazenamento
Store at -80°C
Enviado em
Dry ice packs + Cold packs
Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.
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