SRX3207 - 10mM in DMSO , CAS No.2254693-15-5

CAS: 2254693-15-5 Cat. No.: S422709 Fórmula: C₂₉H₂₉N₇O₃S  Peso molecular: 555.65 PubChem CID: 137357450

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

SRX3207 is an orally active dual inhibitor ofSyk-PI3Kwith IC50 of 39.9 nM, 31200 nM, 3070 nM, 3070 nM, 244 nM, 388 nM, 9790 nM forSyk,Zap70,BRD41,BRD42,PI3K alpha,PI3K delta,PI3K gamma, respectively. SRX3207 blocks tumor immunosuppression and increases anti-tumor immunity.

Targets

Syk (cell-free assay); PI3K alpha (cell-free assay); PI3K delta (cell-free assay); BRD41 (cell-free assay); BRD42 (cell-free assay) 32131,39.9 nM; 244 nM; 388 nM; 3070 nM; 3070 nM

In vivo

SRX3207 blocks both PI3K and Syk in MΦs thereby activating innate and adaptive antitumor immunity in vivo.

Specifications

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

SRX3207 is an orally active dual inhibitor of Syk-PI3K with IC50 of 39.9 nM, 31200 nM, 3070 nM, 3070 nM, 244 nM, 388 nM, 9790 nM for Syk, Zap70, BRD41, BRD42, PI3K alpha, PI3K delta, PI3K gamma, respectively. SRX3207 blocks tumor immunosuppression and inc

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Propriedades do produto

• ALogP: 4.59
• Contagem HBD: 1
• Ligação rotativa: 7

Nomes e identificadores

• Pubchem Sid: 528767203
• Sorrisos canónicos: CC1=NN(C=C1CN2CCC2)C3=NC(=NC=C3)NC4=CC=C(C=C4)C5=CSC6=C5OC(=CC6=O)N7CCOCC7
• IUPAC Name: 3-[4-[[4-[4-(azetidin-1-ylmethyl)-3-methylpyrazol-1-yl]pyrimidin-2-yl]amino]phenyl]-5-morpholin-4-ylthieno[3,2-b]pyran-7-one
• InChIKey: ZZVOPDBZUNUMPR-UHFFFAOYSA-N
• INCHI: 1S/C29H29N7O3S/c1-19-21(16-34-9-2-10-34)17-36(33-19)25-7-8-30-29(32-25)31-22-5-3-20(4-6-22)23-18-40-28-24(37)15-26(39-27(23)28)35-11-13-38-14-12-35/h3-8,15,17-18H,2,9-14,16H2,1H3,(H,30,31,32)
• PubChem CID: 137357450
• Peso molecular: 555.65

Propriedades químicas e físicas

• DMSO (mg/mL) Solubilidade máxima: 33
• DMSO (mM) Solubilidade máxima: 59.3899037163682
• Água (mg/mL) Solubilidade máxima: ＜1
• Peso molecular: 555.700 g/mol
• XLogP3: 4.000
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 7
• Exact Mass: 555.205 Da
• Monoisotopic Mass: 555.205 Da
• Topological Polar Surface Area: 126.000 Ų
• Heavy Atom Count: 40
• Formal Charge: 0
• Complexity: 923.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1