Stattic - 10mM in DMSO , CAS No.19983-44-9

CAS: 19983-44-9 Cat. No.: S407764 Fórmula: C₈H₅NO₄S Peso molecular: 211.19 Número CE: 633-746-6 PubChem CID: 2779853

GRADE & PURITY 10mM in DMSO

Synonyms

Benzo[b]thiophene, 6-nitro-, 1,1-dioxide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

Stattic, the first nonpeptidic small molecule, potently inhibitsSTAT3activation and nuclear translocation withIC50of 5.1 μM in cell-free assays, highly selectivity over STAT1. Stattic inducesapoptosis.
In vitro

Stattic inhibits binding of a phosphotyrosine-containing peptide derived from the gp130 receptor to the STAT3 SH2 domain in a strongly temperature-dependent manner. Stattic only has a very weak effect on binding of a tyrosinephosphorylated peptide to the SH2-domain of the tyrosine kinase Lck. And it doesn’t inhibit dimerization of two other dimeric transcription factors (c-Myc/Max and Jun/Jun). It also inhibits fluorescein-labeled phosphopeptides to the SH2 domains of STAT1 and STAT5b. Stattic selectively inhibits DNA binding of STAT3 homodimers at a concentration of 10 μM. Shown to inhibit cellular phosphorylation of STAT3 at Tyr705 with little effect towards STAT1 phosphorylation at Tyr701 (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells). Stattic increases the apoptotic rate of STAT3-dependent breast cancer cell lines.

In vivo

Cell Data

cell lines：COS1, Hepa or SH-SY5Y cells

Concentrations：~2.5 μM

Incubation Time：48 h

Powder Purity:≥98%

Specifications

Sinónimos

Benzo[b]thiophene, 6-nitro-, 1,1-dioxide

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1. Stattic induces apoptosis.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Nomes e identificadores

SMILES isoméricas

C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-]

WGK Alemanha

3

PubChem CID

2779853

Peso molecular

211.19

Alvos associados (humanos)

HIF1A Tchem Hypoxia-inducible factor 1-alpha (1 Activities)

Discover Target: HIF1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propriedades químicas e físicas

• Solubilidade: Solubility (25°C) In vitro DMSO: 12.5 mg/mL (40.15 mM)
• Índice de refração: 1.67
• Ponto de ebulição (°C): 461.1° C
• Ponto de fusão (°C): 186 - 188 °C

Perguntas frequentes

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 19983-44-9, the molecular formula is C8H5NO4S, and the molecular weight is 211.19 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.