Tinidazole - Moligand™, 10mM in DMSO , DNA inhibitor, CAS No.19387-91-8, DNA inhibitor

CAS: 19387-91-8 Cat. No.: T407955 Fórmula: C₈H₁₃N₃O₄S Peso molecular: 247.27 Número CE: 243-014-4 PubChem CID: 5479

GRAU & PUREZA Moligand™, 10mM in DMSO

Synonyms

CP12574 | 1H-Imidazole, 1-[2-(ethylsulfonyl)ethyl]-2-methyl-5-nitro-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

Tinidazole Tinidazole (CP12574) is an anti-parasitic drug.
In vitro

Tinidazole kills the metronidazole-susceptible isolates at a low MLC but is effective against only 4 of the 12 metronidazole-resistant isolates. Tinidazole exhibits activity against pathogenic protozoa (eg, Tricbomonas vaginalis, Entamoeba bistolytica, Giardia duodenalis), a wide range of clinically significant anaerobic bacteria (eg, Bacteroides fragilis, Clostridium difficile), and the microaerophilic bacterium Helicobacter pylori. Tinidazole is reduced to cytotoxic intermediates that covalently bind to DNA, causing irreversible damage in susceptible protozoal and bacterial cells. Tinidazole inhibits against 104 T. vaginalis isolates with mean MLC of 1014.9 μM. Tinidazole slightly affects trophozoite morphology, adherence and viability against Giardia duodenalis. Tinidazole is against 40 Clostridium difficile, 10 Prevotella bivia and 11 Bacteroides fragilis clinical isolates, the geometric mean MICs of tinidazole and metronidazole are, respectively: C. difficile, 0.31 μg/mL and 0.28 μg/mL; P. bivia, 2.33 μg/mL and 1.52 μg/mL; B. fragilis, 0.5 μg/mL and 0.71 μg/mL.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Especificações

Sinónimos

CP12574 | 1H-Imidazole, 1-[2-(ethylsulfonyl)ethyl]-2-methyl-5-nitro-

Especificações e pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos e fisiológicos

Tinidazole (CP12574) is an anti-parasitic drug.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Tipo de ação

INHIBITOR

Mecanismo de ação

DNA inhibitor

Nomes e identificadores

SMILES isoméricas

CCS(=O)(=O)CCN1C(=NC=C1[N+](=O)[O-])C

RTECS

NI6255000

PubChem CID

5479

Peso molecular

247.27

Reaxy-Rn

618182

Propriedades químicas e físicas

• Solubilidade: Solubility (25°C) In vitro DMSO: 100 mg/mL (162.21 mM); Water: Insoluble; Ethanol: Insoluble
• Ponto de fusão (°C): 129 °C