Tolfenamic Acid - Moligand™, 10mM in DMSO , Inhibitor of AKR1C3, CAS No.13710-19-5, Inhibitor of AKR1C3

CAS: 13710-19-5 Cat. No.: T407845 Fórmula: C₁₄H₁₂ClNO₂ Peso molecular: 261.7 Número CE: 237-264-3 PubChem CID: 610479

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

2-​[(3-​chloro-​2-​methylphenyl)​amino]​-benzoic acid

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

Tolfenamic Acid is aCOX-2inhibitor withIC50of 0.2 μM.
In vitro

In vivo

Cell Data

cell lines：RF/MT-2 strains

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

Sinónimos

2-​[(3-​chloro-​2-​methylphenyl)​amino]​-benzoic acid

Especificações e pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos e fisiológicos

Tolfenamic Acid is a COX-2 inhibitor with IC50 of 0.2 μM.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Tipo de ação

INHIBITOR

Mecanismo de ação

Inhibitor of AKR1C3

Nomes e identificadores

• SMILES isoméricas: CC1=C(C=CC=C1Cl)NC2=CC=CC=C2C(=O)O
• WGK Alemanha: 3
• RTECS: CB2687500
• PubChem CID: 610479
• Peso molecular: 261.7
• Reaxy-Rn: 657821

Alvos associados (humanos)

TTR Tclin Transthyretin (1 Activities)

Discover Target: TTR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKR1C3 Tchem Aldo-keto reductase family 1 member C3 (2 Activities)

Discover Target: AKR1C3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propriedades químicas e físicas

• Solubilidade: Solubility (25°C) In vitro DMSO: 62 mg/mL (186.25 mM)
• Ponto de fusão (°C): 209-214°C

Referências

1. Guanqiong Na, Xiaofei Hu, Yaning Sun, Guangxu Xing, Yunrui Xing, Gaiping Zhang.  (2020)  A novel gold particle-based paper sensor for sensitively detecting carprofen in bovine muscle.  FOOD AND AGRICULTURAL IMMUNOLOGY,      [PMID:] [10.1080/09540105.2020.1740178]

2. Xinyi Wang, Shijie Xu, Lina Jia, Yujia Yang, Yu Liu, Junbo Gong, Songgu Wu.  (2019)  Drug–drug salts of mefenamic acid\tolfenamic acid and piperazine to improve physicochemical properties for potential veterinary use.  CRYSTENGCOMM,  21  (35): (5284-5291).  [PMID:] [10.1039/C9CE00781D]

3. Xue Shu-Wen, Li Jing, Xu Li.  (2017)  Preparation of magnetic melamine-formaldehyde resin and its application to extract nonsteroidal anti-inflammatory drugs.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  409  (12): (3103-3113).  [PMID:28224244] [10.1007/s00216-017-0251-8]

4. Luo Zhi-yuan, Li Zhi-yong, Liu Hai-yan, Tang Min-qiong, Shi Zhi-guo.  (2015)  Click chemistry-based synthesis of water-dispersible hydrophobic magnetic nanoparticles for use in solid phase extraction of non-steroidal anti-inflammatory drugs.  MICROCHIMICA ACTA,  182  (15): (2585-2591).  [PMID:] [10.1007/s00604-015-1638-x]