USP7/USP47 inhibitor - 10mM in DMSO , CAS No.1247825-37-1

CAS: 1247825-37-1 Cat. No.: U656523 Molecular Weight: 484.4 PubChem CID: 51031028

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

USP7/USP47 inhibitor is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC 50 s of 0.42 μM and 1.0 μM, respectively.

In Vitro

USP7/USP47 inhibitor (compound 14) is a selective inhibitor of USP7/USP47 with EC 50 s of 0.42 μM and 1 μM, respectively. USP7/USP47 inhibitor does not inhibit caspase 3, calpain 1, 20S proteasome, and a panel of representative USPs (USP2, USP5, USP8, USP21, and USP28; EC 50 > 31.6 μM). USP7/USP47 inhibitor inhibits the growth of HCT-116 cells with an EC 50 of 7.6 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:EC50: 0.42 μM (USP7), 1.0 μM (USP47)

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

USP7/USP47 inhibitor is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC 50 s of 0.42 μM and 1.0 μM, respectively.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: CS(=O)(=O)C1=CC=C(C=C1)NC(=O)C2=CC(=C(S2)SC3=C(C=NC=C3Cl)Cl)C#N
• PubChem CID: 51031028
• Molecular Weight: 484.4

Associated Targets(Human)

USP7 Tchem Ubiquitin carboxyl-terminal hydrolase 7 (0 Activities)

Discover Target: USP7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

USP47 Tchem Ubiquitin carboxyl-terminal hydrolase 47 (0 Activities)

Discover Target: USP47

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)