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WRR139 - ≥99% , CAS No.2138924-36-2
AVAILABLE TO ORDER
GRADE & PURITY ≥99%
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
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Why this grade
≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
WRR139 is a peptide vinyl sulfone involving in disease processes such as inflammation and cancer . WRR139 is also a cytosolic enzyme N-glycanase 1 (NGLY1) and Nrf1 inhibitor. WRR139 enhances Carfilzomib cytotoxicity against cancer cells.
Form:Solid
In Vitro:WRR139 (0.01-100 μM; 1 h) inhibits NGLY1 in vitro and impairs processing of Nrf1 in HEK293 cells. WRR139 (5 μM; 18 h) disrupts Nrf1 processing, location, and activation in HEK293 cells. WRR139 (1 μM; 24 h) enhances the cytotoxicity of Carfilzomib in an NGLY1-dependent manner in U266, H929, and Jurkat cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Specifications
Specifications & Purity
≥99%
Biochemical and Physiological Mechanisms
WRR139 is a peptide vinyl sulfone involving in disease processes such as inflammation and cancer . WRR139 is also a cytosolic enzyme N-glycanase 1 (NGLY1) and Nrf1 inhibitor. WRR139 enhances Carfilzomib cytotoxicity against cancer cells.
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Purity
≥99%
Names and Identifiers
| Canonical Smiles | CC1=CC=C(C=C1)S(=O)(=O)C=CC(=O)NC(CCC2=CC=CC=C2)C(=O)NCCC(C)C |
|---|---|
| IUPAC Name | (2S)-N-(3-methylbutyl)-2-[[(E)-3-(4-methylphenyl)sulfonylprop-2-enoyl]amino]-4-phenylbutanamide |
| InChIKey | BLEQGDOEDLJWCG-NGIFANIDSA-N |
| INCHI | 1S/C25H32N2O4S/c1-19(2)15-17-26-25(29)23(14-11-21-7-5-4-6-8-21)27-24(28)16-18-32(30,31)22-12-9-20(3)10-13-22/h4-10,12-13,16,18-19,23H,11,14-15,17H2,1-3H3,(H,26,29)(H,27,28)/b18-16+/t23-/m0/s1 |
| PubChem CID | 135300204 |
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
3D Structure
Interactive Chemical Structure Model
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
| Solubility | DMSO : 100 mg/mL (219.01 mM; Need ultrasonic) |
|---|
Solution Calculators
Reviews
Customer Reviews
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