YK11 - 10mM in DMSO , CAS No.1370003-76-1

CAS: 1370003-76-1 Cat. No.: Y656702 Fórmula: C₂₅H₃₄O₆ Peso molecular: 430.53 PubChem CID: 119058028

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

YK11 is a partial agonist of androgen receptor , with osteogenic activity.

In Vitro

YK11 is a partial agonist of androgen receptor, and induces myogenic differentiation of C2C12 Cells at 500 nM via Fst mRNA upregulation by AR. YK11 enhances Myf5 and myogenin mRNA expression, but requires high concentrations (YK11, 100?nM or 500?nM). YK11 (0.5?μM) increases the cell growth of osteoblastic MC3T3-E1 cells, and enhances ALP activity via AR. YK11 also elevates osteoprotegerin mRNA expression (0.5?μM) and dose-dependently increases osteocalcin mRNA expression (0.1-1.0 μM). In addition, YK11 enhances phosphorylation of Akt protein via rapid non-genomic signaling. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Androgen receptor

Specifications

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

YK11 is a partial agonist of androgen receptor , with osteogenic activity.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Nomes e identificadores

• SMILES isoméricas: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@]24/C(=C\C(=O)OC)/OC(O4)(C)OC)CCC5=CC(=O)CC[C@H]35
• CAS alternativo: 1370003-76-1
• PubChem CID: 119058028
• Termos de entrada MeSH: 17,20-((1-methoxyethylidene)bis(oxy))-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester;YK11 cpd
• Peso molecular: 430.53