5,7-Dimethoxyluteolin - ≥98% , CAS No.90363-40-9

CAS: 90363-40-9 Cat. No.: D650969 Molecular Weight: 314.29 PubChem CID: 13964548

GRADE & PURITY ≥98%

Synonyms

MFCD18450948 | 2-(3,4-DIHYDROXYPHENYL)-5,7-DIMETHOXYCHROMEN-4-ONE | 3 inverted exclamation mark ,4 inverted exclamation mark -Dihydroxy-5,7-dimethoxyflavone | AKOS030552896 | AC8592 | HY-111928 | 2-(3,4-Dihydroxyphenyl)-5,7-dimethoxy-4H-1-benzopyran-4-one

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

5,7-Dimethoxyluteolin, a 5,7-dimethylluteolin derivative, is a dopamine transporter (DAT) activator with an EC 50 of 3.417 μM

Form:Solid

IC50& Target:EC50: 3.417 μM (Dopamine transporter)

Specifications

Synonyms

MFCD18450948 | 2-(3, 4-DIHYDROXYPHENYL)-5, 7-DIMETHOXYCHROMEN-4-ONE | 3 inverted exclamation mark , 4 inverted exclamation mark -Dihydroxy-5, 7-dimethoxyflavone | AKOS030552896 | AC8592 | HY-111928 | 2-(3, 4-Dihydroxyphenyl)-5, 7-dimethoxy-4H-1-benzopyran-4-one

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

5, 7-Dimethoxyluteolin, a 5, 7-dimethylluteolin derivative, is a dopamine transporter (DAT) activator with an EC 50 of 3.417 μM.

Storage

Protected from light, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ACTIVATOR

Purity

≥98%

Names and Identifiers

• Canonical Smiles: COC1=CC2=C(C(=C1)OC)C(=O)C=C(O2)C3=CC(=C(C=C3)O)O
• IUPAC Name: 2-(3,4-dihydroxyphenyl)-5,7-dimethoxychromen-4-one
• InChIKey: NKGJZNRUAGQIRY-UHFFFAOYSA-N
• INCHI: 1S/C17H14O6/c1-21-10-6-15(22-2)17-13(20)8-14(23-16(17)7-10)9-3-4-11(18)12(19)5-9/h3-8,18-19H,1-2H3
• Isomeric SMILES: COC1=CC2=C(C(=C1)OC)C(=O)C=C(O2)C3=CC(=C(C=C3)O)O
• Alternate CAS: 90363-40-9
• PubChem CID: 13964548
• Molecular Weight: 314.29

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Phenylpropanoids and polyketides
    • Class Flavonoids
      • Subclass O-methylated flavonoids

• Kingdom: Organic compounds
• Superclass: Phenylpropanoids and polyketides
• Class: Flavonoids
• Subclass: O-methylated flavonoids
• Intermediate Tree Nodes: Not available
• Direct Parent: 7-O-methylated flavonoids
• Alternative Parents: 5-O-methylated flavonoids 3'-hydroxyflavonoids 4'-hydroxyflavonoids Flavones Chromones Anisoles Catechols 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Alkyl aryl ethers Pyranones and derivatives Benzene and substituted derivatives Vinylogous esters Heteroaromatic compounds Oxacyclic compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 5-methoxyflavonoid-skeleton - 7-methoxyflavonoid-skeleton - Hydroxyflavonoid - Flavone - 3'-hydroxyflavonoid - 4'-hydroxyflavonoid - Chromone - 1-benzopyran - Benzopyran - Catechol - Phenol ether - Anisole - 1-hydroxy-4-unsubstituted benzenoid - Alkyl aryl ether - Pyranone - Phenol - 1-hydroxy-2-unsubstituted benzenoid - Monocyclic benzene moiety - Benzenoid - Pyran - Vinylogous ester - Heteroaromatic compound - Organoheterocyclic compound - Oxacycle - Ether - Organic oxide - Organic oxygen compound - Hydrocarbon derivative - Organooxygen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as 7-o-methylated flavonoids. These are flavonoids with methoxy groups attached to the C7 atom of the flavonoid backbone.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

SLC6A3 Tclin Dopamine transporter (10535 Activities)

Discover Target: SLC6A3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (318.18 mM; Need ultrasonic)
• Molecular Weight: 314.290 g/mol
• XLogP3: 1.500
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 314.079 Da
• Monoisotopic Mass: 314.079 Da
• Topological Polar Surface Area: 85.200 Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 476.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1