ABBV-CLS-484 - ≥99% , CAS No.2489404-97-7

CAS: 2489404-97-7 Cat. No.: A646953 Fórmula: C₁₇H₂₄FN₃O₄S Peso molecular: 385.45 PubChem CID: 155103607

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

ABBV-CLS-484 is a potent PTPN1 and PTPN2 inhibitor with subnanomolar activity. ABBV-CLS-484 has antitumor activity, enhances the immune response and increases the sensitivity of tumors to immune-mediated killing.

In Vitro

ABBV-CLS-484 acts on both tumor cells and the host immune system, inducing unique transcriptional changes in the myeloid and lymphocyte populations of the tumor microenvironment, enhancing CD 8+ T cell activation and effector functions while reducing the expression of genes classically associated with T cell depletion and dysfunction. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ABBV-CLS-484 promotes anti-tumor immunity as a monotherapy and, when combined with anti-PD-1, leads to significant tumor regression, even in models resistant to anti-PD-1 treatment, such as 4T1 and EMT6. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

Specifications

Especificaciones y pureza

≥99%

Mecanismos bioquímicos y fisiológicos

ABBV-CLS-484 is a potent PTPN1 and PTPN2 inhibitor with subnanomolar activity. ABBV-CLS-484 has antitumor activity, enhances the immune response and increases the sensitivity of tumors to immune-mediated killing.

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Pureza

≥99%

Nombres e identificadores

• Isómeros SMILES: CC(C)CCN[C@@H]1CCC2=CC(=C(C(=C2C1)F)N3CC(=O)NS3(=O)=O)O
• PubChem CID: 155103607
• Peso molecular: 385.45

Propiedades químicas y físicas

• Solubilidad: DMSO : 62.5 mg/mL (162.15 mM; Need ultrasonic)
• Peso molecular: 385.500 g/mol
• XLogP3: 2.100
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 5
• Exact Mass: 385.147 Da
• Monoisotopic Mass: 385.147 Da
• Topological Polar Surface Area: 107.000 Ų
• Heavy Atom Count: 26
• Formal Charge: 0
• Complexity: 624.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Preguntas frecuentes

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2489404-97-7, the molecular formula is C17H24FN3O4S, and the molecular weight is 385.45 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.