Ac-FLTD-CMK - ≥98% , CAS No.2376255-48-8

CAS: 2376255-48-8 Cat. No.: A414490 Fórmula: C₂₆H₃₇ClN₄O₈ Peso molecular: 569.05

GRADE & PURITY ≥98%

Synonyms

N-acetyl-Phe-Leu-Thr-Asp-chloromethylketone

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Descripción general

Information

Ac-FLTD-CMK is a specific inhibitor for inflammatory caspases . Ac-FLTD-CMK inhibits gasdermin D (GSDMD) cleavage by caspases-1, -4, -5, and -11 in vitro. Ac-FLTD-CMK is effective against caspases-1, caspases-4 and caspases-5 with IC50 of 46.7 nM, 1.49 μM and 329 nM, respectively.

Targets

caspases-1 (Cell-free assay); caspases-5 (Cell-free assay); caspases-4 (Cell-free assay) 46.7 nM; 329 nM; 1.49 μM

In vitro

A GSDMD-derived inhibitor, N-acetyl-Phe-Leu-Thr-Asp-chloromethylketone (Ac-FLTD-CMK), inhibits GSDMD cleavage in vitro and suppresses pyroptosis downstream of both canonical and noncanonical inflammasomes.

In vivo

Ac-FLTD-CMK inhibits pyroptosis and exerts neuroprotective effect in a mice model of traumatic brain injury.

Cell Research(from reference)

Cell lines：BMDM cells 

Concentrations：10 μM 

Incubation Time：30 mins 

Specifications

Sinónimos

N-acetyl-Phe-Leu-Thr-Asp-chloromethylketone

Especificaciones y pureza

≥98%

Condiciones de almacenamiento de almacenamiento

Protected from light,Store at -20°C,Argon charged

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Pureza

≥98%

Nombres e identificadores

Pubchem Sid

528763243

Sonrisas canónicas

CC(C)CC(C(=O)NC(C(C)O)C(=O)NC(CC(=O)O)C(=O)CCl)NC(=O)C(CC1=CC=CC=C1)NC(=O)C

IUPAC Name

(3S)-3-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-acetamido-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-5-chloro-4-oxopentanoic acid

InChIKey

UCWNTWGHVCSMJP-WPUDHWPRSA-N

INCHI

1S/C26H37ClN4O8/c1-14(2)10-19(30-24(37)20(28-16(4)33)11-17-8-6-5-7-9-17)25(38)31-23(15(3)32)26(39)29-18(12-22(35)36)21(34)13-27/h5-9,14-15,18-20,23,32H,10-13H2,1-4H3,(H,28,33)(H,29,39)(H,30,37)(H,31,38)(H,35,36)/t15-,18+,19+,20+,23+/m1/s1

Peso molecular

569.05

Reaxy-Rn

57566578

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=57566578&ln=

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 100 mg/mL (175.73 mM); Ethanol: 25 mg/mL (43.93 mM); Water: 2 mg/mL (3.51 mM)
• Sensibilidad: Hygroscopic ;Light sensitive