AD57 - 10mM in DMSO , CAS No.1093380-42-7

CAS: 1093380-42-7 Cat. No.: A656632 Fórmula: C₂₂H₂₀F₃N₇O Peso molecular: 455.44

CALIDAD & PUREZA 10mM in DMSO

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

AD57 is an orally active multikinase inhibitor, inhibits RET , BRAF , S6K and Src , with greatly reduces mTOR activity

In Vitro

AD57 (0.2 nM) significantly inhibits the ptc > dRet MEN2B lethality in the larva of Drosophila. AD57 (0.1 nM) enhances survival of ptc > dRet MEN2B by reducing erk gene dosage in Drosophila. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AD57 inhibits the viability of MEN2B (MZ-CRC-1) and MEN2A (TT) patient-derived cell lines in RET MEN2 models . AD57 (20 mg/kg) significantly inhibits TT-based tumour growth without obvious cytotoxicity in conventional mouse xenograft model . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Braf

Especificaciones

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

AD57 is an orally active multikinase inhibitor, inhibits RET , BRAF , S6K and Src , with greatly reduces mTOR activity.

Condiciones de almacenamiento de almacenamiento

Protected from light,Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Nombres e identificadores

Peso molecular

455.44